LG Sciences Ghenerate 4oz

One of the best GH supplements!

Growth hormone replacement therapy is one of the fastest growing products on the market, at the moment.Unfortunately, parents probably do not want to inject themselvesevery day in order to look younger. I had read about GHRP-2 and GHRP-6 and I was intrigued although, they show great promiseaccording to research, these two peptide hormones are sold as injectibles. To assess them, I thought that maybe I could try them under the tongue to get a more intense penetration. To my pleasant surprise, I discovered that there was some serious potential in them as I was certainly not going to givemy parentssome homeopathic "GH" or deer velvet that I knew did not work and quite frankly pi**ed me off.

I started looking heavily into growth hormone release and I saw that there are two main pathways. The first I've discussed, which is the GHRP pathway or the Growth Hormone Secretagogue receptor. Furthermore, Ghrelin and GHRP-6/GHRP-2 stimulate this. This pathway is very potent at releasing GH and is a good route, yet there are more potent routes of growth hormone release which is why we needed a two-phase technology to get the job done.

Unfortunately, GHRP-2 and GHRP-6 are illegal to sell in the US, since they are drugs and 100% synthetic so, I began searching for a more naturalingredient that could be used. Luckily, I found a peptide in the fruit of Marus Alba that mimic's the effect of GHRP and it's natural analog Ghrelin (2).I want to make clear that Peptide is not Ghrelin, but does exactly what synthetic peptides like GHRP-6 and GHRP-2 do, stimulate the GHSR receptor.

GHRH is the other receptor that allows for large increases in growth hormone (up to 12 times baseline). By stimulating this receptor you cause massive spikes in circulating GH. GHRH is a stimulating supplement that is found in GHenerate, to boost growth hormone levels even higher. This pathway is totally new to the sports supplement world and the next paragraph details the GHRH agonist.

Puerariae Radix is a plant that has one particular constituent called Puerarin which is an amazing nutrient that shows a 520% increase in growth hormone release (1) by stimulating the GHRH receptor. The key factor is the liquid "under the tongue" bioavailability which makes it biologically active. 520% increase in circulating GH is amassive increase andpotency is further increased when releasing GH.Only 98% pure Puerarin with Cyclodextrin is in this product which is why potency is furthered. Puerarin has also been shown to be an anti-aromatase, and a natural SERM, but this is not the main effect, compared to the GHRH stimulation, which issimply a side benefit (3, 4). Finally, this wonder ingredient is a natural phosphoinositol 3 kinase (PI3K) stimulator which is the same anabolic pathway stimulated by IGF-1 and insulin to load the muscle with glycogen. I have to say, even I am impressed by this amazing material. GHRH stimulation, Aromatase Inhibition, natural SERM activity AND PI3K activity all means results for you the paying customer!

GHenerate has an amazing body recomp, appetite increasing effects that were experienced by our testers and which make it the most potent GH secreting agent produced. One tester gained 8lbs on GHenerate alone, which is unheard of for a GH product. GHenerate is unique in its product range.

What about IGH-1? IGH-1,and GH works in a totally different manner, which is to reduce somatostatin, meaning it will enhance and increase the potential of GHenerate. Somatostatin is the natural hormone your body produces to reduce GH production, so blocking this is a very good thing to do with GHenerate, so stacking the two is going to give exponential results.

Preliminary clinical trial confirms data showing GHenerate with IGH-1 increase growth hormone by up to 5834%

In a landmark, groundbreaking preliminary clinical trial, three healthy humans wanting to optimize their growth hormone levels, used a protocol of LG Sciences IGH-1 and GHenerate to increase their growth hormone levels. The three participants under medical care used the supplements in a "5 on 2 off" protocol taking the supplements as directed before noon and prior to going to sleep. The testing protocol quantified 24 hour growth hormone levels in the urine, which is considered the "best" method for calculating growth hormone. The initial pg/24hr measurements for the three patients was 436, 676 and 169 pg/24 hours and the final results were 801, 2694 and 9850 pg/24 hours.To say these results are amazing are an understatement. The averaged increase was 1042% for the group and larger clinical studies are planned. This study partially confirms the preliminary rodent data that was the inspiration for the two supplements. Ghenerate contains a patent pending blend of Puerarin and Marus Alba extract whichindicates potential for growth hormone potentiation. IGH-1 contains a blend of ingredients shown in research to potentially reduce somatostatin levels, which works in a synergistic way with GHenerate to increase Growth Hormone levels.
Reference Studies:
1) Horm Metab Res. 2004 Feb;36(2):86-91. Induction of growth hormone release by Pueraria thunbergiana BENTH. Jung DY, Ha H, Kim C. Drug Research and Development Team, Korea Institute of Oriental Medicine, 129-11 Chungdam-dong, Kangnam-ku, Seoul 135-100, Korea.

Puerariae Radix (PR), Puerariae Flos (PF), and Puerariae Surculus (PS) as well as their constituents were tested for induction of rat growth hormone (rGH) release by both rat pituitary cell culture and in vivo experimentation in order to develop them to novel drugs. Through a calibration curve of the rGH released by addition of rat growth hormone-releasing hormone (rGHRH) to rat pituitary cells, the 70 % ethanol extracts of PR and PS increased rGH release by about 1.6 and 1.7 times as high, respectively, as the control group (264.6 +/- 13.6 pM). However, each puerarin type as a representative constituent of PR in Korea Pharmacopeia (KP) and tectorigenin and an important ingredient of PF were twice as effective as in the control group. The acid hydrolysate of Puerariae Surculus (HPS) increased rGH release concentration-dependently, and its EC (50) was approximately 10.4 microg/ml. The T (max) value for rGH after injection of 20 microg/kg of rGHRH was 10 - 30 min, while the C (max) value was increased by approximately 12-fold compared to the control group (198.2 +/- 25.0 pM) and the AUC (0 - 45) was increased to 10 times the level of the control group (10,840.9 +/- 845.5 min. pM). On the other hand, T (max) for the HPS was 60 min, while C (max) was increased approximately to 5.8 fold compared to control (244.1 +/- 36.4 pM). C (max) for puerarin was 1,028.6 +/- 502.7 pM, that is, approximately 5.2 times as high as the control level. However, tectorigenin (20 microg/kg) was of no statistical significance. Therefore, we suggest that the HPS and puerarin act either on GH secretagogue receptors or on GHRH receptor of somatotrophin as possible agonists or an inhibitor on somatostatin receptor to release rGH, respectively.

2) Peptides. 2006 Jul;27(7):1597-602. Epub 2006 Feb 17. Ghrelin in plants: what is the function of an appetite hormone in plants? Aydin S Department of Biochemistry and Clinical Biochemistry, School of Medicine, Firat University, Firat Medical Center, 23119 Elazig, Turkey.

There is compelling evidence for the expression of a ghrelin-like peptide hormone that has only been associated with animals, in various plant tissues. Ghrelin, the appetite stimulating hormone, has been identified from a number of different species including humans, rat, pig, mouse, gerbil, eel, goldfish, bullfrog and chicken. The study here was conducted using an immunohistochemistry assay, to screen whether plants have any ghrelin immunoreactivity. In this respect, Prunus x domestica L. and Marus alba were examined. Immunohistochemistry results showed that there is a strong human ghrelin immunoreactivity substance in the parenchyma cells of these plants.It was anunexpected find since this hormone was considered to be present solely in animals thus, this study is the first to report the presence of a peptide with ghrelin-like activity in plants.In addition,this discovery has only been observed in the animal kingdom. RIA analysis confirmed that these plants contain significant amounts of this substance. Furthermore, reverse-phase HPLC analyses of plant extracts showed an elution characteristic of the peptide identical to that of human ghrelin. In general, fruit from both plants had higher levels of the peptide than the vegetative parts.

3) Food Chem Toxicol. 2008 Dec;46(12):3671-6. Epub 2008 Sep 23. Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. Li Y, Chen H, Yang S, Xie G. Cancer Hospital of Tianjin, Tianjin Medical University, Ti-Yuan-Bei, Tianjin 330060, China. liyanwei127@hotmail.com

4) Toxicol Appl Pharmacol. 2008 Dec 15;233(3):371-81. Epub 2008 Sep 19. Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1. Hwang YP, Jeong HG.
 

INGREDIENTS LIST

Hydroxy Propyl Beta Cyclodextrin, Puerarin 98%, GHRP - Marus Alba Extract, Citric Acid, Soy Lecithin, Potassium Sorbate Calcium EDTA(freshness), Sodium Benzoate, Sucralose, Natural and Artificial Flavor, Purified Water, Chitosan.