Estradiol is the strongest form of estrogen in the human body, effecting several organs. Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor (ER alpha and ER beta). When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Epistane works by binding and deactivating the ER beta so that no estrodiol-elicited effects can be carried out in the cell. In the case of breast tissue ER beta is the primary target receptor responsible for growth and proliferation. Epistane binds to the ER beta and not only disables the receptor from binding to estradiol, it actually puts the cell in an estrogen deprived state, which decreases the cells viability and leads to a decrease in size and eventual cell death. Other SERMs also block the ER beta receptor and AI’s even block the formation of Estradiol from testosterone conversion. However, the effectiveness at the receptor and long term side effects vary. Epistane has been shown to have one of the strongest and longest effects at the binding site, with minimal side effects when compared to other anti-estrogens.
Epistane - Increasing Lean Body Mass
Epistane also binds to androgen receptors located on skeletal muscle cells and muscle stem cells. This then leads to changes in muscle cell function and protein synthesis. In the case of muscle stem cells, they will actually change and fuse with your active adult skeletal muscles increasing the muscles potential for growth and repair. On the opposing side, the presence of androgens actually decreases the ability of stem cells to form new fat cells. So you now have increased stem cell conversion to muscle cells and decreased stem cell conversion to fat cells, giving you more positive effects out of your nutrition and training.
What is pulse cycling? (posted in the Epistane forum at IBE, written by Dr.D) Dosing Epistane to intentionally avoid long term sides, such as HTPA suppression and liver damage. With pulsing, the serious, long term side effects of chronic oral treatment are avoided and short term side effects, like acne and mineral retention, are milder than usual. This allows for higher dosages of Epistane to be used. Basically, if you dosed on an ED basis you would get 100% effect, 100% short term sides and 100% long term sides. If you dose EOD on a pulse protocol, you still get about 60% effect, 75% short term sides but only about 40% of the long term sides. That's not a bad trade off and very economical on the body and the wallet too! Of course if you would have gained 10lbs this means you will only gain 6lbs pulsing, but it also means you can do this for 2 or3 times longer than a normal cycle. That equals about 2 months of worry free dosing, so the net effect is a gain of about 12lbs instead of10lbs over twice the time frame with less sides and a milder PCT requirement if even needed at all. It's a great long term strategy and good for newer users looking to run fast, clean, cycles for 1 month with no PCT needed later. That's how I perfected it. There are two basic approaches to do it: EOD or 2on/2off depending on your workout schedule. Doses can be high (30-40mg) but take them close together preferably before 6pm (1 dose pre and 1 dose post-w/o instead of spreadout like normal) or doses can be lower (10-20mg) if you want to stretch it to 2 or 3 months instead of just 1. Dose at least 3 times per weekbut not more than 4. How Epistane Works Battling Gyno Using Epistane Estradiol is the strongest form of estrogen in the human body, affecting several organs. Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell and regulate gene transcription which leads to formation of messenger RNA.The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Epistane works by binding and deactivating the ER alpha so that no estrodiol-elicited effects can be carried out in the cell. In the case of breast tissue ER alpha is the primary target receptor responsible for growth and proliferation. Epistane binds to the ER alpha and not only disables the receptor from binding to estradiol, it actually puts the cell in an estrogen deprived state, which decreases the cells viability and leadsto a decrease in size and eventual cell death. Other SERMs also block the ER alpha receptor and AI’s even block the formation of Estradiol from testosterone conversion. However, the effectiveness at the receptor and long term side effects vary. Epistane has been shown to have one of the strongest and longest effects at the binding site, with minimal side effects when compared to other anti-estrogens. Epistane Increasing Lean Body Mass Epistane also binds to androgen receptors located on skeletal muscle cells and muscle stem cells. This then leads to changes in muscle cell function and protein synthesis. In the case of muscle stem cells, they will actually change and fuse with your active adult skeletal muscles increasing the muscles potential for growth and repair. On the opposing side, the presence of androgens actually decreases the ability of stem cells to form new fat cells. So you now have increased stem cell conversion to muscle cells and decreased stem cell conversion to fat cells, giving you more positive effects out of your nutrition and training. So there you have it. Along with IBE's new fat burner X-force, we expect Epistane will take the bodybuilding world by storm. The complete solution for lean muscle gains is now here at last!
Stacking Options:
We suggest combining Epistane with a product from our liver support category for overall health. For enhanced gains, run this with Activate Xtreme which by binding to SHGB will enhance the effectiveness of the Epistane. Post cycle we recommend combining Epistane with Lean Xtreme and Activate Xtreme to help sustain the muscle gains. For more information on post cycle treatment methods review our article on post cycle treatment in the articles section of the website highlighted at the top of the page.
