Progenadrex: Supplement Profile


Progenadrex: Supplement Profile

Since its debut in early 2015, Fusion Progenadrex has gathered very consistent, rave reviews. Gains of 1lb/week in lean body mass, a simultaneous reduction in body fat and PH like pumps have been widely reported. This feedback is eerily reminiscent of Mass Pro Synthagen, and it’s little wonder: Progenadrex was formulated by the same man (Rob Regish). If you’re still on the fence, read on as this will help you make an informed decision as to whether it’s right for you… We want to explain what Progenadrex is, how it works and what it can do for you.

Progenadrex, at its most basic level, is designed to magnify the most powerful non-steroidal anabolic you can put into your body: food. The result is a completely unique product, unlike anything we've ever seen, which is formulated with goal of adding significant quantities of muscle, but not fat.

It does this through some innovative, exciting ingredients. Let's take a look at some of them.

Anacyclus pyrethrum Ethanol Extract (5:1)

First off is this little mouthful of a substance. In 2010 researchers at the Hari Singh Gour University in India published the results of an animal study showing Anacyclus stimulated the sexual behaviour of rats in a way that resembled the effect of testosterone.[1] The researchers had already established how Anacyclus boosts the synthesis of testosterone. Specifically, doubling it. We’ll see why that’s important later, but for now know that it provides an androgen boost so coveted by athletes. More importantly this ingredient is the king of substrate storage, swelling the muscle cell with glycogen. By all accounts, you’ll crave more carbs and realize much greater muscle fullness. Remember, the suffix is hydrate. For every gram of glycogen stored, your body pulls in nearly 3 grams of water with it, effectively tripling muscle cell volume. So you'll need your carbs when running it, but they'll all be going to the right place: Muscle and NOT fat. What's curious about Anacyclus is this: Only the ethanol extract (thus far) has been tested and found to double testosterone. "Supplementation of anacyclus pyrethrum ethanolic root extract (50-150mg/kg) over 28 days in rats noted dose-dependent increases in testosterone and luteinizing hormone to approximately two-fold of baseline." Which brings us to…  


Lax is an ingredient I know well, perhaps better than anyone in the industry given my 20 year history with it. It’s no stretch to say I’ve used every Lax product going back to the original Mesobolin, put out by Amino Discounters in the early 1990’s. Without question, it's ability to re-partition nutrients (especially carbs) in the muscle cell is extraordinary. However, most (but not all) companies have been missing a key qualifier for Laxogenin to exert its full effects: an optimal test level. For example, one of Dr. Syrov’s papers details Laxogenin and how it works. From “An Experimental Study On The Anabolic Activities of 6-Keto Derivatives Of Some Natural Sapogenins”, “Castratration of the rats resulted in 26% less growth vs. intact rats of the same age”. In the even rarer companion paper I have, “Novel, Natural and Non Hormonal Anabolic Agents Derived From Plants”, this point is again hammered home, “Castration of the animals weakens the anabolic effects of Laxogenin”. So, to make the most of laxogenin you need high testosterone levels - meaning that the laxogenin works in perfect synergy with the anacyclus pyrethrum.

Creatine HCL

It's generally agreed that creatine hydrochloride is a LOT more soluble in water than monohydrate. Due to its higher solubility, the recommended dose is much lower than that for monohydrate. De facto, there is no loading dose necessary, nor mixing up grams of gritty powders or bloat. I don't partake in the mono vs kre-alkaly, vs XYZ wars. It's creatine, it works. We know this… There are things that boost uptake, utilization and the amount you can cram into muscle though, as we'll soon see.  

R-ALA/Biotin/Creatine Uptake

It’s unquestionably the R isomer of alpha-lipoic acid that displays greater bioligical activity.[2] It does however, deplete the body of biotin. You'll notice chapped lips if you don't supplement it separately. Progenadrex has you covered.. There's also evidence it facilitates greater creatine storage.[3] That, along with its other benefits, warrants its inclusion for us.

R-ALA/Laxogenin Synergy

I spoke earlier of Laxogenin’s anti-inflammatory effects. The former owner of Beyond-A-Century (who at the time carried “Anabolica”, an exceptional Lax product) told me he sold, “caseloads” to lupus patients and other persons afflicted with pro-inflammatory conditions. Little known fact: When you REALLY scrub the research on R-ALA, it isn’t the glucose disposal/anti-oxidant or other benefits that stand out. It’s the anti-inflammatory effects seen in HUMAN studies, that really grabs your attention. “In humans, a clinical trial noted a 15% serum reduction in levels of interleukin-6 (an inflammatory marker) following 4 weeks of 300mg racemic ALA supplementation.”[4] Thus, the Laxogenin/R-ALA tag team works better and faster to increase protein synthesis, improve creatine uptake and especially squelch inflammation leading to incredibly fast recovery. Finally, we get to...  

Di Sodium Phosphate

Most companies miss the boat on this one: Sodium is even more important for creatine uptake than insulin.[5] By providing a precise dose along with creatine HCL and R-ALA, you maximize creatine uptake. It’s faster, it works better and your results come quicker.[6]

Final Thoughts

Progenadrex is one of the most exciting and promising supplements we've seen in a long time. Its unique combination of ingredients and the reviews it has been getting all point to this being the single most powerful non-hormonal muscle builder on the market today. Bottom line? If you’ve ever struggled with gaining muscle while staying lean, don't miss this once in a lifetime product. This is your chance to experience the kind of gains most people only read about. Check out our forum and see what our community have been saying about it!


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[1] [Zhong Xi Yi Jie He Xue Bao. 2010 Aug;8(8): 767-73.]

[2] [Am J Physiol. 1997 Jul;273(1 Pt 1):E185-91.]



[5] Willot CA, Young ME, Leighton B, et al. Creatine uptake in isolated soleus muscle: kinetics and dependence on sodium, but not on insulin. Acta Physiol Scand. 1999;166:99-104.

[6] Brault and Terjung, 2003