Citrus aurantium is a fruit of the rutaceae family and extracts of it have been used in dietary supplements as weight loss products. The weight loss effects of this fruit have been attributed to the lipolytic and thermogenic effects of the alkaloids found in it.

Octopamine is an alkaloid found in citrus aurantium, and its isopropyl derivitaive, “isopropyloctopamime” has been used for its lipolytic action. Studies have show that Isopropyloctopamime is a potent fat loss alkaloid that is present in citrus aurantium. Even at doses as low as 1ug/ml this reproduced more than 60% of isoprenaline maximal effect in human adipocytes. Octopamine is able to inhibit glucose uptake into fat cells via activation of the β3 adrenoreeptor (β3-AR). Octopamine can be metabolised in fat cells by monoamino oxidase (MAO) tor form a biproduct of creatine hydrogen peroxide which itself activates AMPK. AMPK plays a crucial role in cellular energy homeostasis, largely to activate glucose and fatty acid uptake and oxidation when cellular energy is low.  

Alongisde this, oxtopamine activates  α1, an adrenergic receptor that enhances lipolysis. 

A recent study by Mercader et Al found that “Isopropylnorsynephrine (isopropyloctopamime) is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in citrus aurantium". 

The impressive lipolytic capacities of isopropyloctopamine are considered to be a good candidate that promotes lipid mobilisation.

Fusion Supplements have isolated this powerful ingredient to help individuals with fat loss.

Stohs SJ. Physiological functions and pharmacological and toxicological effects of p-octopamine. Drug Chem Toxicol. (2014)