Hydrapharm: Alchemy

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Alchemy 60 Capsules

Details

The Strongest AI ever released
  • Stronger inhibition of estrogen than formestane, arimistane and aminogluthemide
  • Increases muscle density and strength
  • Burns fat and lowers water retention
  • Increases natural testosterone leading to quicker gains in size and strength
  • Improved libido and mood
  • Reduces inflammation in adipose tissue leading to fat loss
  • Potent glucose disposal properties leads to enhanced glycogen storage in muscles and loss of body fat
  • Direct activation of SIRT1 increases muscle insulin sensitivity
 5 REVIEWS
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Why

Alchemy was carefully engineered to fulfill a single purpose: To inhibit aromatase as strongly as possible, so that estrogen levels decline dramatically and rapidly. The endocrine shift Alchemy elicits will not only help to prevent the estrogenic side-effects of androgens, it'll eliminate water-retention, increase free testosterone, and improve your performance at the gym.

When

Alchemy is an extremely potent aromatase inhibitor, the strongest non-hormonal supplement class there is. As such, it should be used in cycles of 4-8 weeks with 4 weeks off before commencing use again.

Who

Alchemy is very versatile delivering muscle and performance gains alongside fat loss. It is ideal for men seeking to optimise their endocrine profile by boosting natural testosterone and simultaneously reducing estrogen.

Predator Nutrition Alchemy Review

Hydrapharm have waited a long time to release a new supplement. As a company devoted to introducing only the very best, state of the art supplements on the market it has taken a long time to produce a follow up to the phenomenally successful Adamantine, a muscle builder with incredible recovery enhancing properties, that has become one of the best selling supplements ever at Predator Nutrition.

With Alchemy, Hydrapharm have once again produced a product with no peers. Quite simply, they have introduced something to the market with ingredients that have never been seen before in sports nutrition but which has huge promise based on extensive scientific research. Here is what they have to say on Alchemy.

Hydrapharm Alchemy Description

Alchemy contains Flavozole -- a flavan derivative which is structurally similar to epicatechin, naringenin, and related compounds. Flavans such as Flavozole are ubiquitous throughout nature and are commonly found in tea and chocolate.

But Flavozole is unique. It is, simply put, the most potent AI that the supplement world has ever seen. Studies have demonstrated tremendous inhibitory potency (IC50 = 41nm) at human placental aromatase [1], which is a staggering 127x (!) more potent than aminogluthemide (brand name Cytadren) and is also significantly more potent than that old standby, formestane. In effect, we've rendered every other AI obsolete.

Alchemy also contains dehydroabiatic acid, a potent natural AI isolated from the resin of commiphora myrrha. Although nearly 10x less potent than Flavozole, there were many very good reasons for its inclusion:

  • It reduces inflammation in adipose tissue [2] and in macrophages [3] and may therefore assist with both weight loss and with the joint pain associated with low estrogen levels.

  • A reduction in adipose tissue inflammation should reduce aromatase gene espression. [4]

  • It should possess a different pharmacokinetic profile and a different rate of cellular distribution and uptake when compared to Flavozole. The combination of the two agents should therefore help ensure that estrogen levels decline quickly and remain low.

  • It's a potent glucose-disposal agent [2], which should help shuttle glucose into muscle cells.

  • It directly activates SIRT1 [5], which has anti-aging effects, and increases insulin sensitivity in skeletal muscle.

  • Naringenin is a mild aromatase inhibitor. Its inclusion in Alchemy is due to the fact that it has recently been identified as a ligand for human sex-hormone binding globulin (SHBG). [6,7]

  • Naringenin is the only small natural molecule which binds to SHBG with high affinity & is capable of displacing natural steroids at physiological concentrations. Therefore, when it binds to SHBG, it displaces testosterone and estradiol, resulting in high free concentrations of those hormones. With the aforementioned two ingredients having driven estradiol levels into the ground, naringenin serves primarily to boost levels of free, bioavailable testosterone.

1. Pouget C, Fagnere C, Basly JP, Habrioux G, Chulia AJ. Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition. Bioorg Med Chem Lett. 2002;12(20):2859-61.
2.  Kang MS, Hirai S, Goto T, et al. Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice. Biofactors. 2009;35(5):442-8.
3. Kang MS, Hirai S, Goto T, et al. Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation. Biochem Biophys Res Commun. 2008;369(2):333-8.
4. Polari L, Yatkin E, Martínez chacón MG, et al. Weight gain and inflammation regulate aromatase expression in male adipose tissue, as evidenced by reporter gene activity. Mol Cell Endocrinol. 2015;412:123-30.
5. Kim J, Kang YG, Lee JY, et al. The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1. Mol Cell Endocrinol. 2015;412:216-25.
6. Déchaud H, Ravard C, Claustrat F, De la perrière AB, Pugeat M. Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG). Steroids. 1999;64(5):328-34.
7. Hodgert Jury H, Zacharewski TR, Hammond GL. Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands. J Steroid Biochem Mol Biol. 2000;75(2-3):167-76.

 

96%
 5 REVIEWS
Awesome!!

Great stuff I feel stronger and burn fat in the stomach area :) Love it

Top notch

Have to say I was very impressed by this. Dry, hard and vascular is the look it gives which tells me it is crushing estrogen and boosting test as promised.

The Strongest AI ever - 7 days on and No Joke!!

I previously have had tremendous results using the original 'Strongest AI' on the market, but I can honestly say this was far beyond the strength of anything I have ever used! Personally I react very well to AI's, I always maintain a low BF so the water retention disappearing is easily visible whilst the obvious estrogenic fat accumulating areas of the body tighten almost immediately! I have seen huge gains in strength, endurance and I feel great! After the first 7 days and seeing such a dramatic response I decided to diet HARD on this and cannot describe how good these have been, fat has melted away, I am harder than ever and strength has increased??!!! Yes! Buy this, buy 2 bottles and don't even debate with yourself. The science is there, the results are real!

Best Natural Test Booster

Having used a lot of different test booster (activate xtreme, formestane, ATD, Erase etc), I rate this as the best of them all.rnrnAlchemy kicked in for me just 3-4 days - my muscle looked noticeably harder and more dry. This stuff must really kill estrogen because even my skin was drier. Libido was significantly higher for me at the same time as was muscle fullness and strength.rnrnAfter using it for 4 weeks I had gained significantly in the gym - I went from doing 40kg on incline dumbbell presses for 3 sets of 5 to doing 45kg for 4 sets of 6, that's on an exercise where the most I had ever done for 45kg had been 3 reps previously.rnrnAcross the board I have seen strength gains while I got a lot of compliments in the gym and a few even said I must be on prohormones.rnrnThis is a top notch product, Hydrapharm are making some fantastic products right now for building muscle and this is right up there.

Great product!

First time using this product and I got to say I'm impressed with the product! Really helped me get rid of the excess water weight and my stress levels have dropped. Not only that but it definitely improved my muscle fullness and pumps inside and outside of the gym.

Alchemy 60 Capsules
Predator Review
Predator Nutrition Alchemy Review

Hydrapharm have waited a long time to release a new supplement. As a company devoted to introducing only the very best, state of the art supplements on the market it has taken a long time to produce a follow up to the phenomenally successful Adamantine, a muscle builder with incredible recovery enhancing properties, that has become one of the best selling supplements ever at Predator Nutrition.

With Alchemy, Hydrapharm have once again produced a product with no peers. Quite simply, they have introduced something to the market with ingredients that have never been seen before in sports nutrition but which has huge promise based on extensive scientific research. Here is what they have to say on Alchemy.

Hydrapharm Alchemy Description

Alchemy contains Flavozole -- a flavan derivative which is structurally similar to epicatechin, naringenin, and related compounds. Flavans such as Flavozole are ubiquitous throughout nature and are commonly found in tea and chocolate.

But Flavozole is unique. It is, simply put, the most potent AI that the supplement world has ever seen. Studies have demonstrated tremendous inhibitory potency (IC50 = 41nm) at human placental aromatase [1], which is a staggering 127x (!) more potent than aminogluthemide (brand name Cytadren) and is also significantly more potent than that old standby, formestane. In effect, we've rendered every other AI obsolete.

Alchemy also contains dehydroabiatic acid, a potent natural AI isolated from the resin of commiphora myrrha. Although nearly 10x less potent than Flavozole, there were many very good reasons for its inclusion:

  • It reduces inflammation in adipose tissue [2] and in macrophages [3] and may therefore assist with both weight loss and with the joint pain associated with low estrogen levels.

  • A reduction in adipose tissue inflammation should reduce aromatase gene espression. [4]

  • It should possess a different pharmacokinetic profile and a different rate of cellular distribution and uptake when compared to Flavozole. The combination of the two agents should therefore help ensure that estrogen levels decline quickly and remain low.

  • It's a potent glucose-disposal agent [2], which should help shuttle glucose into muscle cells.

  • It directly activates SIRT1 [5], which has anti-aging effects, and increases insulin sensitivity in skeletal muscle.

  • Naringenin is a mild aromatase inhibitor. Its inclusion in Alchemy is due to the fact that it has recently been identified as a ligand for human sex-hormone binding globulin (SHBG). [6,7]

  • Naringenin is the only small natural molecule which binds to SHBG with high affinity & is capable of displacing natural steroids at physiological concentrations. Therefore, when it binds to SHBG, it displaces testosterone and estradiol, resulting in high free concentrations of those hormones. With the aforementioned two ingredients having driven estradiol levels into the ground, naringenin serves primarily to boost levels of free, bioavailable testosterone.

1. Pouget C, Fagnere C, Basly JP, Habrioux G, Chulia AJ. Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition. Bioorg Med Chem Lett. 2002;12(20):2859-61.
2.  Kang MS, Hirai S, Goto T, et al. Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice. Biofactors. 2009;35(5):442-8.
3. Kang MS, Hirai S, Goto T, et al. Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation. Biochem Biophys Res Commun. 2008;369(2):333-8.
4. Polari L, Yatkin E, Martínez chacón MG, et al. Weight gain and inflammation regulate aromatase expression in male adipose tissue, as evidenced by reporter gene activity. Mol Cell Endocrinol. 2015;412:123-30.
5. Kim J, Kang YG, Lee JY, et al. The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1. Mol Cell Endocrinol. 2015;412:216-25.
6. Déchaud H, Ravard C, Claustrat F, De la perrière AB, Pugeat M. Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG). Steroids. 1999;64(5):328-34.
7. Hodgert Jury H, Zacharewski TR, Hammond GL. Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands. J Steroid Biochem Mol Biol. 2000;75(2-3):167-76.

 

Customer Reviews
96%
 5 REVIEWS
Awesome!!

Great stuff I feel stronger and burn fat in the stomach area :) Love it

Top notch

Have to say I was very impressed by this. Dry, hard and vascular is the look it gives which tells me it is crushing estrogen and boosting test as promised.

The Strongest AI ever - 7 days on and No Joke!!

I previously have had tremendous results using the original 'Strongest AI' on the market, but I can honestly say this was far beyond the strength of anything I have ever used! Personally I react very well to AI's, I always maintain a low BF so the water retention disappearing is easily visible whilst the obvious estrogenic fat accumulating areas of the body tighten almost immediately! I have seen huge gains in strength, endurance and I feel great! After the first 7 days and seeing such a dramatic response I decided to diet HARD on this and cannot describe how good these have been, fat has melted away, I am harder than ever and strength has increased??!!! Yes! Buy this, buy 2 bottles and don't even debate with yourself. The science is there, the results are real!

Best Natural Test Booster

Having used a lot of different test booster (activate xtreme, formestane, ATD, Erase etc), I rate this as the best of them all.rnrnAlchemy kicked in for me just 3-4 days - my muscle looked noticeably harder and more dry. This stuff must really kill estrogen because even my skin was drier. Libido was significantly higher for me at the same time as was muscle fullness and strength.rnrnAfter using it for 4 weeks I had gained significantly in the gym - I went from doing 40kg on incline dumbbell presses for 3 sets of 5 to doing 45kg for 4 sets of 6, that's on an exercise where the most I had ever done for 45kg had been 3 reps previously.rnrnAcross the board I have seen strength gains while I got a lot of compliments in the gym and a few even said I must be on prohormones.rnrnThis is a top notch product, Hydrapharm are making some fantastic products right now for building muscle and this is right up there.

Great product!

First time using this product and I got to say I'm impressed with the product! Really helped me get rid of the excess water weight and my stress levels have dropped. Not only that but it definitely improved my muscle fullness and pumps inside and outside of the gym.

Nutrition

Nutrition

Hydrapharm Alchemy 60 capsules
Serving Size: 1 capsule
Servings per container: 60
  Amount Per Serving  
7-hydroxy-4-imidazolyl-flavan 7mg  
Dehydroabiatic acid 40mg  
Naringenin 40mg  
 
Other ingredients: Gelatin, Rice Flour, Magnesium Stearate
Directions For Use
Take one to two capsules daily. Take with food, preferably at lunch and dinnertime.

Nutrition

Hydrapharm Alchemy 60 capsules
Serving Size: 1 capsule
Servings per container: 60
  Amount Per Serving  
7-hydroxy-4-imidazolyl-flavan 7mg  
Dehydroabiatic acid 40mg  
Naringenin 40mg  
 
Other ingredients: Gelatin, Rice Flour, Magnesium Stearate

Hydrapharm: Alchemy

Directions For Use
Take one to two capsules daily. Take with food, preferably at lunch and dinnertime.
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