Everything You Need to Know About Plasma


Everything You Need to Know About Plasma

We've previously discussed several supplements that can help us build muscle this article is around a product to increase endurance. Plasma from Hydrapharm is one of the newest products from a brand that strives to break boundaries.

To help you navigate this article, we've included a table of contents linking to each section:

Plasma FAQ

What is Hydrapharm Plasma?

PLASMA is the latest product by Hydrapharm, a company renowned for producing supplements which offer athletes a natural, yet effective way of supercharging their performance. PLASMA is targeted at those wanting to test the boundaries of endurance performance and aesthetic demands. Combining 7 powerful ingredients targeting various aspects of human biology, PLASMA is unlike any supplement on the market.. 

What is its Biochemistry?

Cynomrium Songaricum

Also known as the Maltese mushroom is a chinese herb containing phenolic compounds, triterpenes, anthocyanins and B-silosterol glucoside.It is harvested and used to strengthen tendons, as an antioxidant and a herb to treat impotence. Because of this effect, it is now being used as a sports supplement to increase blood flow. 
The tannin rich fractions and flavan-3-ol oligomers from the stems of this show potent antioxidant potential. Recent study showed that when rats were supplemented with C.Songaricum, levels of oxidants (malondialdehyde) decreased, whilst levels of GSH-px (glutathione peroxidase – an endogenous enzyme that protects the body from oxidative damage) increased. This functionality can help the body to increase endurance by getting rid of damaging compounds (1).

Cynomrium Songaricum

Schisandra Chinensis

Also known as lemonwood or Chinese Magnolia Vine is a P-glycoprotein inhibitor and can cause retention of pharmaceuticals/Nutraceuticals subject to efflux by P-gp. It is mainly used for muscle gain and exercise, but has minor effects on mood. Its main composition contains Lignans (average of 25mg/g of dried fruit), but also contains triterpenoids (such as quercetin and melatonin)
Schisandra lignans as hormetic anti-oxidants underlies most of the therapeutic, preventative, and (theoretically, not yet demonstrated) life enhancing properties of Schisandra Chinensis in most organ systems Schisandra has been demonstrated to reach (brain, liver, lungs, kidneys, spleen, and heart). Studies have shown circulation increase with supplementation of Schisandra chinensis. It’s proposed that the direct mechanism is due to weak agonism of estrogen receptors, which increases the activity of the NO-cGMP (Nitric oxide, cyclic GMP) pathway and induced endothelial relaxation. This increase in nitric oxide has been noted in both novice and elite athletes.  Increased blood flow may underlie improvements in physical performance (not too thoroughly demonstrated), and may in part contribute to neural and hepatic benefits (2).

Antrodia Camphorata

A mushroom from taiwan with over78 compounds including terpenoids, benzenoids, lignans and benzoquinone derivatives. 
Has anti-inflammatory effects as it increases expression of Nf-Kb pathway in macrophages which inhibits inflammatory compounds such as tumor necrosis factor (TNF-a), interleukin (Il-1B). One major study in mice looked at using Antrodia Camphorata to improve fatigue symptoms. Biochemical variables such as lactic acid, ammonia, glucose and creatine kinase are indicators of muscle fatigue after exercise. Extracts of the fruit of Antrodia Camphorata were shown to have an anti-fatigue effect by decreasing plasma lactate and ammonia levels, increasing blood glucose concentration and liver and muscle glycogen deposition. Overall this elevated exercise performance in these mice (3).

5-Aminolevulinic Acid

A small molecule involved in the early phase of porphryin biosynthesis which is responsible for heme production. A deficiency in this amino acid has been shown to cause impaired glucose tolerance and insulin resistance – which can mean bad sugar levels and increased weight. In a recent study, this amino acid helped increased exercise efficiency through positive alterations of oxidative metabolism (4).


Coenzyme Q10 is probably one of the best known antioxidants. Antioxidants are essential in the body to reduce oxidative stress that can damage muscles, bones and DNA. Oxidative stress is produced naturally day to day in normal cellular metabolism, but specifically it is produced after exercise. This can slow down repair and recovery after sessions. Studies have shown that supplementing with CoQ10 is a great way to reduce this oxidative stress and therefore reduce symptoms of fatigue (5).

Myo-inositol Trispyrophosphate

Myo-inositol trispyrophosphate (ITPP) is an allosteric effector of haemoglobin that increases red blood cells ability to release oxygen. Oxygen delivery is important for maximal muscle function and activity. ITPP is able to cross the red blood cell membrane. ITPP is a synthetic compound derived from myoinositol hexakisphosphate, which is normally produced in mammalian cells and has antioxidant and anti-cancer properties
This means ITPP may increase exercise capacity as it decreases oxygen binding to red blood cells, meaning there is more free oxygen release in the blood travelling to the working muscles (6). 

Cobalt Chloride

A natural salt that is now being used by athletes to increase erythropoietin (red blood cells). It does this through a chain reaction once cobalt chloride is administered. It generates oxygen reactive species which triggers the stabilisation of “hypoxia inducible factor 1a and the transcription of erythropoietin (Epo) genes. This increases Epo in the plasma and therefore improves anaerobic athletic performance. It peaks at 3.2 hours and displays an absorptive half-life of 0.9 hours, an elimination phase half-life of 3.9 hours, and a terminal elimination half-life of 22.9 hours. 
Studies show that hypoxia preconditioning training with cobalt chloride enhances physical performance and protects the muscle from exercised-induced oxidative damage via glutathione, HO-1 and other enzymatic mediated capacities. High levels of cobalt chloride in the body are toxic, but the levels in PLASMA are low that even when taken for the full course, the levels will not build up to toxicity levels (due to half-life of the compound). (7).

cobalt chloride

How does Plasma work then?

PLASMA marks a revolution in what is possible for an endurance booster and whether you are seeking to run a marathon faster, or simply perform more reps in the gym it will deliver on both. It works by targeting multiple aspects of fatigue and endurance in the body. This can be through antioxidant pathways, anti-inflammatory, increasing nitric oxide, increases oxygenation and overall increasing VO2 maximum. . 

Who can use Plasma?

PLASMA is a multi-faceted product and its prolific ingredient panel means athletes from different sports can use it. It can help bodybuilders finish a long and intense session, keeping their energy high, or it can help endurance athletes shave seconds off their time. Each ingredient has been carefully selected to optimise performance by addressing all aspects that limit endurance. 

How long can Plasma be used for?

Due to the nature of the ingredients, PLASMA should be used in cycles for a maximum of 6 weeks, followed by the same amount of time without using it.  

Plasma usage


  • Take 1 capsule with a meal, three times each day. Do not take for more than 6 weeks at a time


  • Improve recovery
  • Increase VO2 Max
  • Boost intracellular muscular endurance
  • Improve Nitric Oxide
  • Improve red blood cell oxygenation

So, to summarise…

  • Plasma contains 7 ingredients to boost performance
  • It can be used as a natural endurance enhancer 
  • Optimal cycles are 6 weeks in length with the same time off
  • It's suitable for men and women and has no reported side effects when dosed correctly

Watch this space for more mystery sports nutrition ingredients

In this series of articles we want to focus our attention on some of the innovative ingredients out there that have been shown to deliver significant improvements in performance or body composition. The difference here is that we will be covering ingredients that are less well known so don't expect a lengthy article on whey protein or BCAAs!

Did you enjoy this article? Was there anything in particular that resonated with you (or riled you)? Do you have any further information that we've missed? Please let us know via our Facebook page. 

1.    Meng HC, Wang A, Li Y, Kuang YY. Chemical constituents and pharmacologic actions of Cynomorium plants. 2013. Chin J Nat Med. 11: 4
2.    Lee YJ, et al. Extracts from Schizandra chinensis fruit activate estrogen receptors: a possible clue to its effects on nitric oxide-mediated vasorelaxation . Biol Pharm Bull. (2004)
3.    Huang CC, Hsu MC, Huang WC.  Triterpenoid-Rich Extract from Antrodia camphorata Improves Physical Fatigue and Exercise Performance in Mic. 2012. Evid Based Complement Alternat Med.
4.    Fujii, C. 5-Aminolevulinic Acid, Aprecusor of Mitocondrial Electron Carrier, Improves Exercise Endurance and Glucose Tolerance through Activation of Muscle Mitochondrial Biogenesis in Saropenic Mice. Nature. 2017. 7: 4013. 
5.    Cooke M., Iosia M., Buford. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr. 2008. 5:8
6.    Duarte C, Greferarth R, Nicolau C, Lehn J. myo-Inositol trispyrophosphate: a novel allosteric effector of hemoglobin with high permeation selectivity across the red blood cell plasma membrane. Chembiochem. 2010. 10:11(18)
7.    G Lippi, M Franchini, G Guidi. Cobalt chloride administration in athletes: a new perspective for blood doping. 2005. British Journal of Sports Medicine. 39:11.

About the Author

Reggie Johal

Reggie Johal is the founder of Predator Nutrition, a UK based health and supplement store. Reggie owes much of his extensive strength and fitness knowledge to his former career as a Great Britain American Footballer.

Want To Learn More?
Get the Latest Articles from Predator Nutrition delivered every week!

Sign up to our exclusive newsletters and be the first to know about best new articles. Please enter your email address and when you are done simply press Subscribe.