Hydrapharm : Cycloastragenol Anti Aging

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Hydrapharm Cycloastragenol 60 Capsules

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https://www.predatornutrition.com/anti-aging-supplements/hydrapharm/HYD1026%2F100%2F101.html
Healthy-ageing support

Goal: Study/Work Aid

  • Anti-aging breakthrough
  • Age with confidence
  • Look after your general wellbeing
  • Keep in control of your energy and mood
  • Sleep deeper than ever
£59.99 £50.99

Price per serving: £1.00

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Hydrapharm Cycloastragenol ingredients & nutrition facts

Hydrapharm Cycloastragenol 60 capsules
Serving Size: 1 capsule
Servings Per Container: 60
  Amount Per Serving %DV**
Cycloastragenol 5mg *
* Daily value not established    
Other ingredients: Microcrystalline Cellulose, Gelatin (capsule), Rice Flour, Magnesium Stearate

Cycloastragenol dosage & how to use

18-49 years old – Take 1-2 capsules daily on an empty stomach.

50-69 years old – Take 2-3 capsules daily on an empty stomach.

70+ years – Take 5 capsules daily on an empty stomach.

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Product Guide

Why

Cycloastragenol is one of the most exciting ingredients when it comes to natural support for healthy aging.

When

Cycloastragenol should be dosed daily all year-round on a long term basis to experience the benefits. Discontinuing usage is not recommended once a user embarks on an anti-aging regimen based around this compound.

Who

Both men and women seeking to age with confidence.

Predator Nutrition Cycloastragenol Review

At Predator Nutrition we always like to provide novel and exclusive products for our customers that are not available elsewhere. The latest product that has us excited at Predator Nutrition HQ is Hydrapharm Cycloastragenol, the most bioactive ingredient in Astragalus root extract, a herb which has a great track record. Astragalus itself has relatively poor solubility and low bioavailability, and with its benefits being derived from cycloastragenol anyway, it explains why cycloastragenol supplements are booming lately with its anti-aging properties with various brand name forms such as CA-98 (98% cycloastragenol content) and TA-65 becoming popular. However, the Hydrapharm Cycloastragenol supplement goes further still in being dosed at over 99% cycloastragenol content making it the best cycloastragenol supplement available in the UK today.

How Does Cycloastragenol Work?

Cycloastragenol works by inhibiting reactive oxygen species generation and attenuates endoplasmic reticulum stress (2). Reactive oxygen species can have a deleterious effect DNA and RNA and plays a negative role in the physiology of aging. Interestingly, the outer face of the rough endoplasmic reticulum is studded with ribosomes that are the sites for protein synthesis.
 
Cycloastragenol specifically stops the inflammatory activation of TXNIP/NLRP3. Inflammatory activation leads to mitochondrial cell death in endothelial cells, but cycloastragenol has the capacity to restore the loss of the mitochondrial membrane potential by preventing caspase-3 activity, resulting in the protection of cells from endoplasmic reticulum stress induced apoptosis. This study found cycloastragenol to be effective in regulating endothelial homeostasis by ameliorating endothelial dysfunction specifically by inhibiting inflammation and reducing cell apoptosis (1).

Cycloastragenol and Telomeres

Telomeres consist of repetitive non-coding DNA sequences located at chromosomes. They play a protective role in the chromosome ends along with shelterin complex. The shelterin complex consists of six telomere associated proteins and allows cells in the body to distinguish telomeres from DNA damage sites. Without this, unprotected teleomeres provoke a DNA damage response (3).
 
Telomere shortening occurs due to the end replication problem in DNA replication – the DNA strand shortens with each cell division, since the DNA polymerase can’t completely replicate the whole strand. As well as this problem, reactive oxygen species and other environmental stress factors lead to telomere damage and increase erosion of the telomere.
 
Cycloastragenol has been shown to activate telomerease in T lymphocytes, helping to inhibit telomere shortening, proliferative potential and enhance functional response. This has made it an interesting area of research in cancer treatment, aging, psychiatric disorders such as depression, atherosclerosis, skin diseases and regenerative medicine (4, 5). Although the research on cycloastragenol is in its early days, it is being proposed as a potential therapeutic answer for anti-aging and telomerase-dependent disease treatments.

Conclusion

Cycloastragenol provides a potent antioxidant that helps to reduce inflammation. This, along with its ability to provide liver protective properties and reduce the activity of reactive oxygen species, makes it relevant to individuals who are constantly engaged in strenuous exercise.
 
It’s ability to reduce endothelium stress and inhibit telemorase shortening has made it a potential therapeutic solution for a number of diseases such as cancer treatment and regenerative medicine.
 
It may be cliché, but further research in human studies is needed on cycloastragenol to determine the specific effects of its wide ranging benefits in specific diseases - the pharmaceutical companies seem to be dragging their feet with further research on cycloastragenol, but at Predator Nutrition we feel we didn’t want you to miss out on this wide-ranging beneficial ingredient.
 
 
1. ZHANG Shi-di;LU Jun-kun;YAN Ji-zhong;ZHANG Hui;Zhejiang. Research progress of the preparation technology and pharmacological effect of cycloastragenol. Chinese Journal of New Drugs. 2016-16.

2.YanZhao, QiangLi, WenjunZhao, JiaLi, YanSun,, KangLiu, BaolinLiu, NingZhang. Astragaloside IV andcycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium. Journal of EthnopharmacologyVolume 169, 1 July 2015, Pages 210-218.
 
3. Kathrin Jäger, Michael Walter. Therapeutic Targeting of Telomerase. Genes 2016, 7(7), 39; doi:10.3390/genes7070039.
  
4. Ip F.C.F, Ng Y.P, An H.J, Dai Y, Pang H.H, Hu Y.Q, Chin A.C, Harley C.B, Wong Y.H, Ip N.Y. Neurosignals. 2014, Vol.22, No. 1.
 
5. Weiss R. Evaluation of a Novel Anti-aging Topical Formulation Containing Cycloastragenol, Growth Factors, Peptides and Antioxidants. Jan Marini Skin Research.

 

98%
 13 genuine reviews
Fantastic

Wow absolutely love this product it's a bit pricey but well worth it

Works to some extent

Don't know if it makes you "younger", been taking it for like 6 months now and I can say that has improved my eyesight a lot, maybe even my hairs got a little bit better, I will keep taking it for at least another 6 months and review the results

Superb

On my second bottle now. Great products but just a little bit pricey. I guess you get what you pay for though!

Eccezionale

Lo uso da circa tre mesi e ne sono molto soddisfatto ! I miglioramenti si notano dopo qualche mese ! Sicuramente continuerò a prenderlo.! Grazie Translation: I've been using it for about three months and I'm very happy with it! The improvements are noticeable after a few months! I will definitely continue to take it.! Thank you

Fantastico

I miglioramenti li ho notati sulla vista.! Vedo molto meglio mi sento alla grande ! Ottimo il recupero ! Grazie Predator Nutrition siete eccezionali..!!! “The improvements I noticed them on sight.! I see much better I feel great! Excellent recovery! Thanks Predator Nutrition you are exceptional .. !!!“

Great

Great product! I noticed my hair's grows back as well! Anyone noticed this too?

A GREAT PRODUCT

This product helps me look and feel healthy!

Great Product

I got this as a free product through my rewards programme. I'm very impressed as it definitely works helping me to focus physically and mentally on whatever I'm doing. I have a very long day getting up at 5.00 am to walk 6.5 miles, a very full on work day requiring me to work intensively and focus the whole time then to the gym in the evening. I'm 60 so not a young spring chicken! This product isn't cheap but it's well worth the money for the results!

Feelgood supplement

I got this via the loyalty program and so glad I did coz this makes me feel so damn happy, and naturally energised. Note to Predator - Your write-up doesn’t emphasise the benefits users are finding in this!

Relax and Focus in a box.

I had this through loyalty points, 'cause I wanted to try it and I didn't want to spend all that money, but you know what? even If I had spent the whole price, I would have been happy to spend it afterward. It relieves me from stress, or, at least makes me manage stressful situations more easily, allowing me to be focused a lot better.

Wonderful, unexpected benefits

I bought this to see if it would have a restorative effect on my skin and it does indeed seem to have helped make my skin feel more taut/smoother than before. However, it is the other effects that are truly remarkable and why I will continue taking this. It is hard to explain really but the best way I can term it is I feel younger. A good example of this is that I noticed I feel more into dance music, a genre I may liked 15 years ago but lost interest in, and I also feel more confident, super confident in fact, more gregarious and just in an all-round good mood. At the same time my energy levels are up with me taking stairs two at a time or running up them even when normally I could not be bothered. Heck, sometimes I will just decide to do some sit-ups and press ups in the living room just because I feel so vibrant! (I think this kind of thing is more likely than not a dopaminergic effect since dopamine declines with age). For anyone who feels they have lost a step, physically or mentally, as a consequence of age, I highly, highly recommend this!

Used for months now.

I am 59 years old. This is a long-term telomere enhancing longevity supplement. I have now used this for many months and can say from my experience there appear to be many anti-aging benefits. I agree it seems expensive but if you wish to optimise your health and appearance this is an option. Hgh is expensive and illegal and one never knows if it is legit. Explore your options. I am constantly ripped and as strong and fit as ever. Skin pretty good. There are many ways to delay the inevitable decay of our bodies. This is one to consider. Julie (my wife) and I are examples of exactly that. Stay young in mind and body.

Very helpful

After a month on this you just feel and look like you've been away on holidays. I intend to use this a few times a year to regenerate myself. I'd say this could be as important as a good liver support like TUDCA. Thanks Predator Nutrition for bringing this to us.

Hydrapharm Cycloastragenol 60 Capsules
Predator Review

Predator Nutrition Cycloastragenol Review

At Predator Nutrition we always like to provide novel and exclusive products for our customers that are not available elsewhere. The latest product that has us excited at Predator Nutrition HQ is Hydrapharm Cycloastragenol, the most bioactive ingredient in Astragalus root extract, a herb which has a great track record. Astragalus itself has relatively poor solubility and low bioavailability, and with its benefits being derived from cycloastragenol anyway, it explains why cycloastragenol supplements are booming lately with its anti-aging properties with various brand name forms such as CA-98 (98% cycloastragenol content) and TA-65 becoming popular. However, the Hydrapharm Cycloastragenol supplement goes further still in being dosed at over 99% cycloastragenol content making it the best cycloastragenol supplement available in the UK today.

How Does Cycloastragenol Work?

Cycloastragenol works by inhibiting reactive oxygen species generation and attenuates endoplasmic reticulum stress (2). Reactive oxygen species can have a deleterious effect DNA and RNA and plays a negative role in the physiology of aging. Interestingly, the outer face of the rough endoplasmic reticulum is studded with ribosomes that are the sites for protein synthesis.
 
Cycloastragenol specifically stops the inflammatory activation of TXNIP/NLRP3. Inflammatory activation leads to mitochondrial cell death in endothelial cells, but cycloastragenol has the capacity to restore the loss of the mitochondrial membrane potential by preventing caspase-3 activity, resulting in the protection of cells from endoplasmic reticulum stress induced apoptosis. This study found cycloastragenol to be effective in regulating endothelial homeostasis by ameliorating endothelial dysfunction specifically by inhibiting inflammation and reducing cell apoptosis (1).

Cycloastragenol and Telomeres

Telomeres consist of repetitive non-coding DNA sequences located at chromosomes. They play a protective role in the chromosome ends along with shelterin complex. The shelterin complex consists of six telomere associated proteins and allows cells in the body to distinguish telomeres from DNA damage sites. Without this, unprotected teleomeres provoke a DNA damage response (3).
 
Telomere shortening occurs due to the end replication problem in DNA replication – the DNA strand shortens with each cell division, since the DNA polymerase can’t completely replicate the whole strand. As well as this problem, reactive oxygen species and other environmental stress factors lead to telomere damage and increase erosion of the telomere.
 
Cycloastragenol has been shown to activate telomerease in T lymphocytes, helping to inhibit telomere shortening, proliferative potential and enhance functional response. This has made it an interesting area of research in cancer treatment, aging, psychiatric disorders such as depression, atherosclerosis, skin diseases and regenerative medicine (4, 5). Although the research on cycloastragenol is in its early days, it is being proposed as a potential therapeutic answer for anti-aging and telomerase-dependent disease treatments.

Conclusion

Cycloastragenol provides a potent antioxidant that helps to reduce inflammation. This, along with its ability to provide liver protective properties and reduce the activity of reactive oxygen species, makes it relevant to individuals who are constantly engaged in strenuous exercise.
 
It’s ability to reduce endothelium stress and inhibit telemorase shortening has made it a potential therapeutic solution for a number of diseases such as cancer treatment and regenerative medicine.
 
It may be cliché, but further research in human studies is needed on cycloastragenol to determine the specific effects of its wide ranging benefits in specific diseases - the pharmaceutical companies seem to be dragging their feet with further research on cycloastragenol, but at Predator Nutrition we feel we didn’t want you to miss out on this wide-ranging beneficial ingredient.
 
 
1. ZHANG Shi-di;LU Jun-kun;YAN Ji-zhong;ZHANG Hui;Zhejiang. Research progress of the preparation technology and pharmacological effect of cycloastragenol. Chinese Journal of New Drugs. 2016-16.

2.YanZhao, QiangLi, WenjunZhao, JiaLi, YanSun,, KangLiu, BaolinLiu, NingZhang. Astragaloside IV andcycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium. Journal of EthnopharmacologyVolume 169, 1 July 2015, Pages 210-218.
 
3. Kathrin Jäger, Michael Walter. Therapeutic Targeting of Telomerase. Genes 2016, 7(7), 39; doi:10.3390/genes7070039.
  
4. Ip F.C.F, Ng Y.P, An H.J, Dai Y, Pang H.H, Hu Y.Q, Chin A.C, Harley C.B, Wong Y.H, Ip N.Y. Neurosignals. 2014, Vol.22, No. 1.
 
5. Weiss R. Evaluation of a Novel Anti-aging Topical Formulation Containing Cycloastragenol, Growth Factors, Peptides and Antioxidants. Jan Marini Skin Research.

 

Customer Reviews
98%
 13 genuine reviews
Fantastic

Wow absolutely love this product it's a bit pricey but well worth it

Works to some extent

Don't know if it makes you "younger", been taking it for like 6 months now and I can say that has improved my eyesight a lot, maybe even my hairs got a little bit better, I will keep taking it for at least another 6 months and review the results

Superb

On my second bottle now. Great products but just a little bit pricey. I guess you get what you pay for though!

Eccezionale

Lo uso da circa tre mesi e ne sono molto soddisfatto ! I miglioramenti si notano dopo qualche mese ! Sicuramente continuerò a prenderlo.! Grazie Translation: I've been using it for about three months and I'm very happy with it! The improvements are noticeable after a few months! I will definitely continue to take it.! Thank you

Fantastico

I miglioramenti li ho notati sulla vista.! Vedo molto meglio mi sento alla grande ! Ottimo il recupero ! Grazie Predator Nutrition siete eccezionali..!!! “The improvements I noticed them on sight.! I see much better I feel great! Excellent recovery! Thanks Predator Nutrition you are exceptional .. !!!“

Great

Great product! I noticed my hair's grows back as well! Anyone noticed this too?

A GREAT PRODUCT

This product helps me look and feel healthy!

Great Product

I got this as a free product through my rewards programme. I'm very impressed as it definitely works helping me to focus physically and mentally on whatever I'm doing. I have a very long day getting up at 5.00 am to walk 6.5 miles, a very full on work day requiring me to work intensively and focus the whole time then to the gym in the evening. I'm 60 so not a young spring chicken! This product isn't cheap but it's well worth the money for the results!

Feelgood supplement

I got this via the loyalty program and so glad I did coz this makes me feel so damn happy, and naturally energised. Note to Predator - Your write-up doesn’t emphasise the benefits users are finding in this!

Relax and Focus in a box.

I had this through loyalty points, 'cause I wanted to try it and I didn't want to spend all that money, but you know what? even If I had spent the whole price, I would have been happy to spend it afterward. It relieves me from stress, or, at least makes me manage stressful situations more easily, allowing me to be focused a lot better.

Wonderful, unexpected benefits

I bought this to see if it would have a restorative effect on my skin and it does indeed seem to have helped make my skin feel more taut/smoother than before. However, it is the other effects that are truly remarkable and why I will continue taking this. It is hard to explain really but the best way I can term it is I feel younger. A good example of this is that I noticed I feel more into dance music, a genre I may liked 15 years ago but lost interest in, and I also feel more confident, super confident in fact, more gregarious and just in an all-round good mood. At the same time my energy levels are up with me taking stairs two at a time or running up them even when normally I could not be bothered. Heck, sometimes I will just decide to do some sit-ups and press ups in the living room just because I feel so vibrant! (I think this kind of thing is more likely than not a dopaminergic effect since dopamine declines with age). For anyone who feels they have lost a step, physically or mentally, as a consequence of age, I highly, highly recommend this!

Used for months now.

I am 59 years old. This is a long-term telomere enhancing longevity supplement. I have now used this for many months and can say from my experience there appear to be many anti-aging benefits. I agree it seems expensive but if you wish to optimise your health and appearance this is an option. Hgh is expensive and illegal and one never knows if it is legit. Explore your options. I am constantly ripped and as strong and fit as ever. Skin pretty good. There are many ways to delay the inevitable decay of our bodies. This is one to consider. Julie (my wife) and I are examples of exactly that. Stay young in mind and body.

Very helpful

After a month on this you just feel and look like you've been away on holidays. I intend to use this a few times a year to regenerate myself. I'd say this could be as important as a good liver support like TUDCA. Thanks Predator Nutrition for bringing this to us.

Nutrition

Hydrapharm Cycloastragenol ingredients & nutrition facts

Hydrapharm Cycloastragenol 60 capsules
Serving Size: 1 capsule
Servings Per Container: 60
  Amount Per Serving %DV**
Cycloastragenol 5mg *
* Daily value not established    
Other ingredients: Microcrystalline Cellulose, Gelatin (capsule), Rice Flour, Magnesium Stearate
Dosage & How to use

Cycloastragenol dosage & how to use

18-49 years old – Take 1-2 capsules daily on an empty stomach.

50-69 years old – Take 2-3 capsules daily on an empty stomach.

70+ years – Take 5 capsules daily on an empty stomach.

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