Hydrapharm : Immortal Anti Aging

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Hydrapharm Immortal 90 Capsules

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https://www.predatornutrition.com/anti-aging-supplements/hydrapharm/HYD1036%2F100%2F101.html
Elite anti-aging stack

Goal: Anti-Aging

  • Combines the two most highly touted anti-aging ingredients in one
  • NMN for enhanced NAD+ levels
  • Pterostilbene for sirtuin activation
  • Supports energy levels
  • Supports benefits across multiple systems
  • Better recovery
£79.98

Price per serving: £0.89

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Hydrapharm Immortal ingredients & nutrition facts

Hydrapharm Immortal 90 Capsules
Serving Size: 1 Capsule
Servings Per Container: 90
  Amount Per Serving %RI*
Nicotinaminde Mononucleotide (MN) 334mg *
Pterostilbene 17mg *
* Reference Intake not Established
Other Ingredients: Corn Starch, Gelatin

Immortal dosage & how to use

Take 1 to 3 capsules every morning with food. The higher dose would be applicable for those who are older or who weigh over 75kg. However, we recommend all users start with one capsule for the first week to assess tolerance.
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Product Guide

Why

Immortal combines 334mg of NMN and 17mg of Pterostilbene per capsule, two compounds designed to work in concert to increase levels of NAD+ in the body. Research on both suggests they can offset the age-related decline in NAD+ with improvements across a host of physiological functions including suppressed inflammation, improved insulin control, extended lifespan, and enhanced mitochondrial function to name just three.

When

Immortal should be used once daily on a ongoing basis year-round to get the best out of it. For most people, starting with one capsule daily in the morning with food, is the best way to supplement Immortal.

Who

By middle age NAD+ levels will be half what they would be in our youth so likely the greatest benefit will be received by those who are aged 40+ although many younger users will take it for the greater energy levels users typically experience

Predator Nutrition Immortal Review

What are NMN and Pterostilbene and what do they do?

Hydrapharm Immortal delivers 334mg of nicotinamide mononucleotide (NMN) and 17mg of pterostilbene per capsule. NMN is a vitamin B3 metabolite which is used in the body to help synthesise NAD+ (nicotinamide adenine dinucleotide). Pterostilbene is a stilbenoid which is found in grapes but has superior bioavailability than resveratrol as well as having a longer half-life.[1]

Pterostilbene and NMN work in a complementary fashion with the former activating sirtuin genes while NMN helps provide the fuel for sirtuins.

What is Immortal good for?

Immortal is good for anyone looking for research backed ingredients which have shown good efficacy for upregulating NAD+ levels, promoting greater energy, and boosting cellular repair.[2] In a nutshell, the studies of NMN and pterostilbene to date show complementary mechanisms by which overall health and vitality is optimised.

What can you expect from using NMN and Pterostilbene?

This is a supplement where you should be able to notice an effect pretty quickly. In general, we would advise starting with one capsule daily in the morning with food and assess tolerance at that dose for a week before considering increasing the dose, especially for younger individuals.

In terms of what you can expect, most users will notice an increase in energy levels meaning where you might normally get fatigued by the evening or after a tough day at work/in the gym, you can expect to find yourself with greater energy reserves enabling you to focus for longer, get tired more slowly. This is one reason why dosing should begin low as user reports, especially among younger populations, indicates a high dose drives energy levels too high such that it can disrupt sleep.

How does NMN help combat aging?

Several studies have shown that the strategy of boosting NAD+ levels can help to reverse a number of age-related issues including enhancing our sensitivity to insulin, reversing mitochondrial dysfunction and, the big one, extending lifespan.[3][4]

Research has shown that we can help enhance the synthesis of NAD+ levels via the inhibition of the CD38 enzyme which degrades NAD+ levels as well as through the supplementation of NAD precursors including both NMN and nicotinamide riboside (NR)[5][6][7]leading to benefits across a host of bodily functions which together help provide a model for improving how well we age, supporting longevity and improving human health./p>

In other words, one should consider NMN as not merely a tool for supporting gains in longevity but a pathway to improving function so that quality of life is improved also.

How does Pterostilbene work?

Pterostilbene, much like its chemical cousin resveratrol, is an antioxidant which helps to combat oxygen mediated damage caused by free radicals. This function alone has its benefits since excessive oxidative stress contributes both to aging and also disease. Furthermore, pterostilbene has been shown to have anti-inflammatory effects which is significant not only because inflammation increases as we age, but also because chronic inflammation is associated with the onset of disease.[8][9]

However, its inclusion in Immortal is primarily due to its activation of sirtuin genes, a family of proteins which help to regulate cellular and mitochondrial function both of which help to mediate the aging process. By taking it in conjunction with NMN the effectiveness of the latter will be increased with pterostilbene’s sirtuin boosting action enabling NMN to engage in its primary function of boosting NAD+ levels as well as supporting improved cognitive function.[10]

In making the decision to include pterostilbene instead of resveratrol Hydrapharm have relied on the evidence showing not merely greater bioavailability and half life as noted previously, but also research which shows pterostilbene exhibited greater potency in reducing inflammation than resveratrol.[11]

Finally, for those who are still on the fence, pterostilbene’s benefits extend to potentially improving body composition with research showing it can act in an anti-obesogenic manner[12] via its potential ability to promote brown fat over white fat (brown fat being notably more thermogenic) as well as showing evidence of supporting better outcomes in diabetic rats.[13]

What other supplements work well with NMN and Pterostilbene?

Aging is associated with more than a decline in NAD+ with impaired hormonal output, increased inflammation, a reduction in muscle mass, increase in fat and poorer joint flexibility being just a few of the other factors which contribute to age-related decline. We covered some of the science behind this in our article on aging healthily but among the supplements which would work best alongside the combination of NMN and pterostilbene found in Immortal, we would pick out the telomerase activator, cycloastragenol which both aligns most closely to the use case for NMN and pterostilbene and which also has a significant degree of research support.[14][15][16][17]

If there was one other product which would fit well into the mix then we would pick out Hydrapharm Elixir, as it contains a number of potent glucose disposal agents which help to optimise insulin sensitivity. While one of the most famous names in the anti-aging space, David Sinclair, uses the prescription drug metformin to improve blood sugar regulation, the combination of ingredients in Elixir (berberine, oxymatrine and ecklonia cava) have been shown to achieve the same with the added bonus of some additional benefits including increased energy expenditure, anti-obesogenic, and better blood lipid levels.[18][19][20][21][22]

What else can help when taking NMN and Pterostilbene?

For users seeking to get the very best from these products, the emerging research suggests that to age healthily a few key things should be done outside of any supplemental intake including maintaining a healthy bodyfat percentage, performing a mix of both resistance and cardiovascular exercise, a healthy diet low in sugar, with intermittent fasting frequently promoted by life extensionists as one way to help deliver the health benefits of fasting without the deleterious consequences of extended fasting.

Immortal Summary

By including both NMN and pterostilbene together, Hydrapharm Immortal incorporates the very best combination of research based anti-aging compounds, which taken independently, both have strong theoretical and research bases to demonstrate their potential to optimise health across a wide array of physiological markers, as well as offering the potential to improve health as we age.

However, due to their synergistic nature, taking them together ensures you get the best from each ingredient and while immortality is impossible for now, you can at least be assured of the very best out there in terms of both ingredient selection and dose for those committed to aging healthily.


[1] Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats (2011): Izet M. Kapetanovic, Miguel Muzzio, and David L. McCormick

[2] Why NAD(+) Declines during Aging: It's Destroyed (2016) Michael B Schultz, David A Sinclair.

[3] Review NAD+ and vitamin B3: from metabolism to therapies (2007): Anthony Suave

[4] Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease (2019): Anthony Suave

[5] CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism (2016): Juliana Camacho-Pereira  et al.

[6] Interventions to Slow Aging in Humans: Are We Ready? (2015): Valter Longo et al.

[7] NAMPT-Mediated NAD Biosynthesis as the Internal Timing Mechanism: In NAD+ World, Time Is Running in Its Own Way (2017): Borut Poljsak

[8] Occurrence, Bioavailability, Anti-inflammatory, and Anticancer Effects of Pterostilbene (2020): Wei-Sheng Lin, Jane Valorie Leland, Chi-Tang Ho*, and Min-Hsiung Pan

[9] Neuroprotective and Anti-inflammatory Effects of Pterostilbene Metabolites in Human Neuroblastoma SH-SY5Y and RAW 264.7 Macrophage Cells (2020): Pablo Peñalver, Sonia Zodio, Ricardo Lucas, María Violante de-Paz, and Juan Carlos Morales

[10] Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study (2019): Martina La Spina et al.

[11] Pterostilbene surpassed resveratrol for anti-inflammatory application: Potency consideration and pharmacokinetics perspective (2014): Qiu-YiChoo, Samuel Chao Ming Yeo, Paul C.Ho, Yoshiya Tanaka, Hai-Shu Lin

[12] Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene (2018): Min-Hsiung Pan, Jia-Ching Wu, Chi-Tang Ho, Ching-Shu Lai

[13] Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin-Induced Diabetic Rats (2018): Bora Tastekin, Aykut Pelit, and Yusuf Kenan Daglioglu

[14] Cycloastragenol: An exciting novel candidate for age-associated diseases (2018): Yongjie Yu et al.

[15] Therapeutic Targeting of Telomerase. Genes (2016): Kathrin Jäger, Michael Walter.

[16] Research progress of the preparation technology and pharmacological effect of cycloastragenol (2016): Zhang Shi-di;Lu Jun-kun;Yan Ji-zhong;Zhang Hui

[17] Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives (2019): soukalas, D., Fragkiadaki, P., Docea, A., Alegakis, A., Sarandi, E., Thanasoula, M., Spandidos, D., Tsatsakis, A., Razgonova, M. and Calina, D

[18] Effects of 12-week oral supplementation of Ecklonia cava polyphenols on anthropometric and blood lipid parameters in overweight Korean individuals: a double-blind randomized clinical trial (2011). Shin HC, Kim SH, Park Y, Lee BH, Hwang HJ.

[19] Effect of phlorotannins isolated from Ecklonia cava on angiotensin I-converting enzyme (ACE) inhibitory activity (2011). Wijesinghe WA, Ko SC, Jeon YJ.

[20] Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance (2008). Jayasooriya AP, Mathai ML, Walker LL, Begg DP, Denton DA, Cameron-Smith D, Egan GF, McKinley MJ, Rodger PD, Sinclair AJ, Wark JD, Weisinger HS, Jois M, Weisinger RS.

[21] Ecklonia cava Inhibits Glucose Absorption and Stimulates Insulin Secretion in Streptozotocin-Induced Diabetic Mice (2012). Hye Kyung Kim

[22] Hypoglycemic and hypolipidemic effects of oxymatrine in high-fat diet and streptozotocin-induced diabetic rats (2014). Guo C et al.

100%
 1 genuine reviews
The Powerhouse of the CELL

started taking this supplement 2 days ago and am now starting to feel the effect on my 25 year old male body! This stuff feels like something jumpstarted my energy leves almost to an ADHD state which feels good! I started training a year ago an before that I have been a lethargic person until I started training. But now this is something else; Good vibe energy!! The one thing i remember vividly in school is that the mithocondria is the powerhouse of the cell and by god is that true with this!! Second day with 1 capsule in the morning and feel amazing, would recommend!

Hydrapharm Immortal 90 Capsules
Predator Review

Predator Nutrition Immortal Review

What are NMN and Pterostilbene and what do they do?

Hydrapharm Immortal delivers 334mg of nicotinamide mononucleotide (NMN) and 17mg of pterostilbene per capsule. NMN is a vitamin B3 metabolite which is used in the body to help synthesise NAD+ (nicotinamide adenine dinucleotide). Pterostilbene is a stilbenoid which is found in grapes but has superior bioavailability than resveratrol as well as having a longer half-life.[1]

Pterostilbene and NMN work in a complementary fashion with the former activating sirtuin genes while NMN helps provide the fuel for sirtuins.

What is Immortal good for?

Immortal is good for anyone looking for research backed ingredients which have shown good efficacy for upregulating NAD+ levels, promoting greater energy, and boosting cellular repair.[2] In a nutshell, the studies of NMN and pterostilbene to date show complementary mechanisms by which overall health and vitality is optimised.

What can you expect from using NMN and Pterostilbene?

This is a supplement where you should be able to notice an effect pretty quickly. In general, we would advise starting with one capsule daily in the morning with food and assess tolerance at that dose for a week before considering increasing the dose, especially for younger individuals.

In terms of what you can expect, most users will notice an increase in energy levels meaning where you might normally get fatigued by the evening or after a tough day at work/in the gym, you can expect to find yourself with greater energy reserves enabling you to focus for longer, get tired more slowly. This is one reason why dosing should begin low as user reports, especially among younger populations, indicates a high dose drives energy levels too high such that it can disrupt sleep.

How does NMN help combat aging?

Several studies have shown that the strategy of boosting NAD+ levels can help to reverse a number of age-related issues including enhancing our sensitivity to insulin, reversing mitochondrial dysfunction and, the big one, extending lifespan.[3][4]

Research has shown that we can help enhance the synthesis of NAD+ levels via the inhibition of the CD38 enzyme which degrades NAD+ levels as well as through the supplementation of NAD precursors including both NMN and nicotinamide riboside (NR)[5][6][7]leading to benefits across a host of bodily functions which together help provide a model for improving how well we age, supporting longevity and improving human health./p>

In other words, one should consider NMN as not merely a tool for supporting gains in longevity but a pathway to improving function so that quality of life is improved also.

How does Pterostilbene work?

Pterostilbene, much like its chemical cousin resveratrol, is an antioxidant which helps to combat oxygen mediated damage caused by free radicals. This function alone has its benefits since excessive oxidative stress contributes both to aging and also disease. Furthermore, pterostilbene has been shown to have anti-inflammatory effects which is significant not only because inflammation increases as we age, but also because chronic inflammation is associated with the onset of disease.[8][9]

However, its inclusion in Immortal is primarily due to its activation of sirtuin genes, a family of proteins which help to regulate cellular and mitochondrial function both of which help to mediate the aging process. By taking it in conjunction with NMN the effectiveness of the latter will be increased with pterostilbene’s sirtuin boosting action enabling NMN to engage in its primary function of boosting NAD+ levels as well as supporting improved cognitive function.[10]

In making the decision to include pterostilbene instead of resveratrol Hydrapharm have relied on the evidence showing not merely greater bioavailability and half life as noted previously, but also research which shows pterostilbene exhibited greater potency in reducing inflammation than resveratrol.[11]

Finally, for those who are still on the fence, pterostilbene’s benefits extend to potentially improving body composition with research showing it can act in an anti-obesogenic manner[12] via its potential ability to promote brown fat over white fat (brown fat being notably more thermogenic) as well as showing evidence of supporting better outcomes in diabetic rats.[13]

What other supplements work well with NMN and Pterostilbene?

Aging is associated with more than a decline in NAD+ with impaired hormonal output, increased inflammation, a reduction in muscle mass, increase in fat and poorer joint flexibility being just a few of the other factors which contribute to age-related decline. We covered some of the science behind this in our article on aging healthily but among the supplements which would work best alongside the combination of NMN and pterostilbene found in Immortal, we would pick out the telomerase activator, cycloastragenol which both aligns most closely to the use case for NMN and pterostilbene and which also has a significant degree of research support.[14][15][16][17]

If there was one other product which would fit well into the mix then we would pick out Hydrapharm Elixir, as it contains a number of potent glucose disposal agents which help to optimise insulin sensitivity. While one of the most famous names in the anti-aging space, David Sinclair, uses the prescription drug metformin to improve blood sugar regulation, the combination of ingredients in Elixir (berberine, oxymatrine and ecklonia cava) have been shown to achieve the same with the added bonus of some additional benefits including increased energy expenditure, anti-obesogenic, and better blood lipid levels.[18][19][20][21][22]

What else can help when taking NMN and Pterostilbene?

For users seeking to get the very best from these products, the emerging research suggests that to age healthily a few key things should be done outside of any supplemental intake including maintaining a healthy bodyfat percentage, performing a mix of both resistance and cardiovascular exercise, a healthy diet low in sugar, with intermittent fasting frequently promoted by life extensionists as one way to help deliver the health benefits of fasting without the deleterious consequences of extended fasting.

Immortal Summary

By including both NMN and pterostilbene together, Hydrapharm Immortal incorporates the very best combination of research based anti-aging compounds, which taken independently, both have strong theoretical and research bases to demonstrate their potential to optimise health across a wide array of physiological markers, as well as offering the potential to improve health as we age.

However, due to their synergistic nature, taking them together ensures you get the best from each ingredient and while immortality is impossible for now, you can at least be assured of the very best out there in terms of both ingredient selection and dose for those committed to aging healthily.


[1] Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats (2011): Izet M. Kapetanovic, Miguel Muzzio, and David L. McCormick

[2] Why NAD(+) Declines during Aging: It's Destroyed (2016) Michael B Schultz, David A Sinclair.

[3] Review NAD+ and vitamin B3: from metabolism to therapies (2007): Anthony Suave

[4] Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease (2019): Anthony Suave

[5] CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism (2016): Juliana Camacho-Pereira  et al.

[6] Interventions to Slow Aging in Humans: Are We Ready? (2015): Valter Longo et al.

[7] NAMPT-Mediated NAD Biosynthesis as the Internal Timing Mechanism: In NAD+ World, Time Is Running in Its Own Way (2017): Borut Poljsak

[8] Occurrence, Bioavailability, Anti-inflammatory, and Anticancer Effects of Pterostilbene (2020): Wei-Sheng Lin, Jane Valorie Leland, Chi-Tang Ho*, and Min-Hsiung Pan

[9] Neuroprotective and Anti-inflammatory Effects of Pterostilbene Metabolites in Human Neuroblastoma SH-SY5Y and RAW 264.7 Macrophage Cells (2020): Pablo Peñalver, Sonia Zodio, Ricardo Lucas, María Violante de-Paz, and Juan Carlos Morales

[10] Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study (2019): Martina La Spina et al.

[11] Pterostilbene surpassed resveratrol for anti-inflammatory application: Potency consideration and pharmacokinetics perspective (2014): Qiu-YiChoo, Samuel Chao Ming Yeo, Paul C.Ho, Yoshiya Tanaka, Hai-Shu Lin

[12] Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene (2018): Min-Hsiung Pan, Jia-Ching Wu, Chi-Tang Ho, Ching-Shu Lai

[13] Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin-Induced Diabetic Rats (2018): Bora Tastekin, Aykut Pelit, and Yusuf Kenan Daglioglu

[14] Cycloastragenol: An exciting novel candidate for age-associated diseases (2018): Yongjie Yu et al.

[15] Therapeutic Targeting of Telomerase. Genes (2016): Kathrin Jäger, Michael Walter.

[16] Research progress of the preparation technology and pharmacological effect of cycloastragenol (2016): Zhang Shi-di;Lu Jun-kun;Yan Ji-zhong;Zhang Hui

[17] Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives (2019): soukalas, D., Fragkiadaki, P., Docea, A., Alegakis, A., Sarandi, E., Thanasoula, M., Spandidos, D., Tsatsakis, A., Razgonova, M. and Calina, D

[18] Effects of 12-week oral supplementation of Ecklonia cava polyphenols on anthropometric and blood lipid parameters in overweight Korean individuals: a double-blind randomized clinical trial (2011). Shin HC, Kim SH, Park Y, Lee BH, Hwang HJ.

[19] Effect of phlorotannins isolated from Ecklonia cava on angiotensin I-converting enzyme (ACE) inhibitory activity (2011). Wijesinghe WA, Ko SC, Jeon YJ.

[20] Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance (2008). Jayasooriya AP, Mathai ML, Walker LL, Begg DP, Denton DA, Cameron-Smith D, Egan GF, McKinley MJ, Rodger PD, Sinclair AJ, Wark JD, Weisinger HS, Jois M, Weisinger RS.

[21] Ecklonia cava Inhibits Glucose Absorption and Stimulates Insulin Secretion in Streptozotocin-Induced Diabetic Mice (2012). Hye Kyung Kim

[22] Hypoglycemic and hypolipidemic effects of oxymatrine in high-fat diet and streptozotocin-induced diabetic rats (2014). Guo C et al.

Customer Reviews
100%
 1 genuine reviews
The Powerhouse of the CELL

started taking this supplement 2 days ago and am now starting to feel the effect on my 25 year old male body! This stuff feels like something jumpstarted my energy leves almost to an ADHD state which feels good! I started training a year ago an before that I have been a lethargic person until I started training. But now this is something else; Good vibe energy!! The one thing i remember vividly in school is that the mithocondria is the powerhouse of the cell and by god is that true with this!! Second day with 1 capsule in the morning and feel amazing, would recommend!

Nutrition

Hydrapharm Immortal ingredients & nutrition facts

Hydrapharm Immortal 90 Capsules
Serving Size: 1 Capsule
Servings Per Container: 90
  Amount Per Serving %RI*
Nicotinaminde Mononucleotide (MN) 334mg *
Pterostilbene 17mg *
* Reference Intake not Established
Other Ingredients: Corn Starch, Gelatin
Dosage & How to use

Immortal dosage & how to use

Take 1 to 3 capsules every morning with food. The higher dose would be applicable for those who are older or who weigh over 75kg. However, we recommend all users start with one capsule for the first week to assess tolerance.
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