Hydrapharm : Immortal Anti Aging

What are NMN and Pterostilbene and what do they do?

Hydrapharm Immortal delivers 334mg of nicotinamide mononucleotide (NMN) and 17mg of pterostilbene per capsule. NMN is a vitamin B3 metabolite which is used in the body to help synthesise NAD+ (nicotinamide adenine dinucleotide). Pterostilbene is a stilbenoid which is found in grapes but has superior bioavailability than resveratrol as well as having a longer half-life.[1]

Pterostilbene and NMN work in a complementary fashion with the former activating sirtuin genes while NMN helps provide the fuel for sirtuins.

What is Immortal good for?

Immortal is good for anyone looking for research backed ingredients which have shown good efficacy for upregulating NAD+ levels, promoting greater energy, and boosting cellular repair.[2] In a nutshell, the studies of NMN and pterostilbene to date show complementary mechanisms by which overall health and vitality is optimised.

What can you expect from using NMN and Pterostilbene?

This is a supplement where you should be able to notice an effect pretty quickly. In general, we would advise starting with one capsule daily in the morning with food and assess tolerance at that dose for a week before considering increasing the dose, especially for younger individuals.

In terms of what you can expect, most users will notice an increase in energy levels meaning where you might normally get fatigued by the evening or after a tough day at work/in the gym, you can expect to find yourself with greater energy reserves enabling you to focus for longer, get tired more slowly. This is one reason why dosing should begin low as user reports, especially among younger populations, indicates a high dose drives energy levels too high such that it can disrupt sleep.

How does NMN help combat aging?

Several studies have shown that the strategy of boosting NAD+ levels can help to reverse a number of age-related issues including enhancing our sensitivity to insulin, reversing mitochondrial dysfunction and, the big one, extending lifespan.[3][4]

Research has shown that we can help enhance the synthesis of NAD+ levels via the inhibition of the CD38 enzyme which degrades NAD+ levels as well as through the supplementation of NAD precursors including both NMN and nicotinamide riboside (NR)[5][6][7]leading to benefits across a host of bodily functions which together help provide a model for improving how well we age, supporting longevity and improving human health./p>

In other words, one should consider NMN as not merely a tool for supporting gains in longevity but a pathway to improving function so that quality of life is improved also.

How does Pterostilbene work?

Pterostilbene, much like its chemical cousin resveratrol, is an antioxidant which helps to combat oxygen mediated damage caused by free radicals. This function alone has its benefits since excessive oxidative stress contributes both to aging and also disease. Furthermore, pterostilbene has been shown to have anti-inflammatory effects which is significant not only because inflammation increases as we age, but also because chronic inflammation is associated with the onset of disease.[8][9]

However, its inclusion in Immortal is primarily due to its activation of sirtuin genes, a family of proteins which help to regulate cellular and mitochondrial function both of which help to mediate the aging process. By taking it in conjunction with NMN the effectiveness of the latter will be increased with pterostilbene’s sirtuin boosting action enabling NMN to engage in its primary function of boosting NAD+ levels as well as supporting improved cognitive function.[10]

In making the decision to include pterostilbene instead of resveratrol Hydrapharm have relied on the evidence showing not merely greater bioavailability and half life as noted previously, but also research which shows pterostilbene exhibited greater potency in reducing inflammation than resveratrol.[11]

Finally, for those who are still on the fence, pterostilbene’s benefits extend to potentially improving body composition with research showing it can act in an anti-obesogenic manner[12] via its potential ability to promote brown fat over white fat (brown fat being notably more thermogenic) as well as showing evidence of supporting better outcomes in diabetic rats.[13]

What other supplements work well with NMN and Pterostilbene?

Aging is associated with more than a decline in NAD+ with impaired hormonal output, increased inflammation, a reduction in muscle mass, increase in fat and poorer joint flexibility being just a few of the other factors which contribute to age-related decline. We covered some of the science behind this in our article on aging healthily but among the supplements which would work best alongside the combination of NMN and pterostilbene found in Immortal, we would pick out the telomerase activator, cycloastragenol which both aligns most closely to the use case for NMN and pterostilbene and which also has a significant degree of research support.[14][15][16][17]

If there was one other product which would fit well into the mix then we would pick out Hydrapharm Elixir, as it contains a number of potent glucose disposal agents which help to optimise insulin sensitivity. While one of the most famous names in the anti-aging space, David Sinclair, uses the prescription drug metformin to improve blood sugar regulation, the combination of ingredients in Elixir (berberine, oxymatrine and ecklonia cava) have been shown to achieve the same with the added bonus of some additional benefits including increased energy expenditure, anti-obesogenic, and better blood lipid levels.[18][19][20][21][22]

What else can help when taking NMN and Pterostilbene?

For users seeking to get the very best from these products, the emerging research suggests that to age healthily a few key things should be done outside of any supplemental intake including maintaining a healthy bodyfat percentage, performing a mix of both resistance and cardiovascular exercise, a healthy diet low in sugar, with intermittent fasting frequently promoted by life extensionists as one way to help deliver the health benefits of fasting without the deleterious consequences of extended fasting.

Immortal Summary

By including both NMN and pterostilbene together, Hydrapharm Immortal incorporates the very best combination of research based anti-aging compounds, which taken independently, both have strong theoretical and research bases to demonstrate their potential to optimise health across a wide array of physiological markers, as well as offering the potential to improve health as we age.

However, due to their synergistic nature, taking them together ensures you get the best from each ingredient and while immortality is impossible for now, you can at least be assured of the very best out there in terms of both ingredient selection and dose for those committed to aging healthily.