Hydrapharm: Revival

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Hydrapharm Revival 30 servings - Improves sleep and mood

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Improves sleep and mood

Goal: Improve Sleep

  • V Vegan
  • Fast acting supplement
  • Enhances non-REM sleep
  • Improves mood
  • Increase GH and IGF-1 naturally
  • Better sleep improves gym performance
  • Be more alert and attentive with improved sleep
£39.98

Price per serving: £1.33

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Nutrition

Hydrapharm Revival 90 Capsules
Servings per container: 30
Serving size: 3 capsules
  Amount Per Serving %DV**
Revival Proprietary Blend (Magnesium Bisglycinate, Valerian, L-Theanine, Safranal, Emoxypine, 5-HTP, 2-Bromomelatonin) 1326mg
* % DV Is based on a 2000kcal daily diet
† Daily Value is not yet established
Other Ingredients: Gelatin, Rice Flour, Hydroxypropyl Beta Cyclodextrin.

Directions For Use

Take three capsules with a small meal or a drink before bedtime.
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Why

Revival utilises a blend of 7 ingredients that provide a host of beneficial effects. Each ingredient works in a unique way to either calm the mental and physical system, promote the onset of sleep or to benefit non-REM sleep. While many of us are aware that sleep duration matters, it is not so commonly understood that sleep quality is just as important. A long sleep, of which the majority is spent in the 'light' phase, may still result in impaired cognition, performance, recovery and even immune function for the subsequent day(s). You may have heard the phrase 'sleep to grow', sleep deprivation causes reductions in anabolic hormones testosterone, GH, and the GH-related growth factor IGF-1, not to mention an increase in cortisol and hunger hormones - a recipe for disaster. Revival quickly optimises every variable that goes toward a good sleep, from time to fall asleep to duration and quality.

When

Revival should be taken 30 minutes before your sleep, especially if you know you have had a particularly stressful day or you need plenty of rest for the next day. For even more pronounced effects, implement lifestyle changes such as cutting off caffeine intake at mid-afternoon and limiting blue light exposure after sundown.

Who

Revival can be used by anyone with it being particularly well suited for those engaged in hard training or having stressful lifestyles. Unlike other sleep supplements, Revival will not have a sedative effect but addresses the root cause of why sleep might be suffering.

Predator Nutrition Revival Review

All-Purpose Supplement for General Health

Hydrapharm have built a reputation for innovation that is second to none in the sports nutrition industry. However, more than innovation they have become industry leaders for products that deliver and deliver big whether the goal is better performance, greater muscle mass, faster recovery, or potent nootropics that you notice from day one.

Their latest product, Revival, falls into the latter category albeit a nootropic that is less about focus and productivity, and more about relaxation and enhancing sleep quality. However, even that underplays the potential benefits since both an understanding from using it and a deep dive of the research behind its ingredients illustrates that Revival is far more than a sleep aid and instead offers a range of benefits that makes it much more akin to the health and wellbeing version of an all-in-one supplement like Quantum.

The Problems with Existing Sleep Aids

The sleep aid category is broadly split into three types of products.

In the first are highly effective ingredients which are both illegal in the EU, but which also have innate issues with them such as rapid habituation that leads to ever greater doses and decreasing effectiveness.

At the extreme end, they include products such as Phenibut which are only possible to be used once or twice a week to avoid both side effects and to actually be effective still. Usually comprising GABA analogues, this class of product are only really useful for those with periodic issues with falling asleep and are a very bad choice for those with frequent issues with falling and staying asleep.

In the second class, are sleep aids you can commonly find sold in health shops, or supermarkets. Containing a range of herbs or minerals, these are generally effective only for those with occasional sleep problems and fail to help anyone with more chronic sleep issues, especially the type of wired individual who finds it a constant struggle to quieten their mind when going to bed. At best, these types of ingredients can provide a useful adjunct to a sleep aid but are not very effective by themselves.

In the final class, we have pharmaceuticals which tend to consist of benzodiazepenes, antihistamines and Z-class drugs such as Zolpidem and Zopiclone. While they will help users to fall asleep and stay asleep when used occasionally they are also rapidly habituated to, have a range of deleterious side effects, and arguably worst of all, are not much good at all due to their failing to deliver the non-rapid eye movement (NREM) sleep that is critical for improving sleep quality. Instead, by taking a sledgehammer approach, you often find yourself more tired and groggy the day after and these all tend to stimulate appetite strongly – the very last thing most athletes need.

Revival - The Best Sleep Aid Designed 

Given the issues with existing sleep aid products, Hydrapharm remarked to us that Revival proved to be the most difficult product they had ever created, both in finding ingredients that avoid the issues with existing sleep aids and to do so with no dimunition in effect over the long term. However, they told us that extensive testing with Revival made them confident that it would not only prove to be effective but to actually work better the longer it was used.

This seemed too good to be true but our own experience with using it appeared to back up their claims, with our users finding that it both helped with sleep onset, maintaining sleep through the night without the periods of wakefulness that can plague other sleep aids, and that not only did it prove effective with repeated use, but it conferred other benefits we had not even expected but are no surprise when you see some of the benefits associated with some of the ingredients in Revival with safranal and emoxypine being particularly noteworthy in this regard.

Once we look at the data behind the ingredients, it becomes apparent that this was no fluke but a consequence of a combination of ingredients with extensive research behind them.

Revival Ingredient Overview

Revival contains seven different ingredients which encompasses both some we have seen before, and then a few which we’ve not encountered before in a sleep aid.

Magnesium

Magnesium is a mineral which plays a key role in a huge range of bodily processes, including everything from regulating muscular contractions,[1]lowering blood pressure[2]and improving blood sugar control[3]to name just a few that can help athletes who are more likely than not to be deficient in this key mineral. 

However, it is magnesium’s effects on insomnia that merit its inclusion within Revival. Studies show magnesium can help adults fall asleep faster and improve both sleep quality and reduce insomnia symptoms,[4]as well as regulate your body’s sleep-wake cycle[5]and bind to GABA receptors which are crucial for calming nerve activity that can otherwise negatively effect your ability to sleep.[6][7]

Magnesium is one of the ingredients that are hardly new to a sleep aid but an often overlooked component of using this ingredient is the type of magnesium used. Not only do magnesium supplements vary widely in their degree of absorption but the cheaper forms prevalent in many supplements can cause gastric distress.

Magnesium Bisglycinate, the form found in Revival is both the best type of magnesium from an absorption standpoint while also avoiding many of the side effects seen with other forms of magnesium.

Valerian

Valerian is a herb which has been used for centuries as a traditional sleep aid and is a no-brainer being both safe and effective with a meta-analysis of 16 studies comfirming its ability to improve sleep quality.[8][9]

Valerian is certainly not a new ingredient but its inclusion within Revival is to help ensure that the formula is not reliant on any one ingredient but instead ensuring sleep is driven through a variety of mechanisms rather than relying on any single ingredient.

L-Theanine

Theanine is an amino acid which has been long overlooked by athletes but has lately been used increasingly as a way of helping to provide relaxation, with one of its uses being paired with stimulants to help manage the anxiety stimulants can sometimes cause.

While its use as a standalone sleep aid is unlikely to deliver many benefits, its inclusion within Revival is due to theanine’s ability to help relax the mind such that your brain switches off at night as well as its ability to both decrease sleep latency and improve the all-important NREM sleep that is linked to improved sleep quality, at least when paired with supporting ingredients that have a sedating effect.[10]

Additionally, research shows that theanine has a positive effect not only on sleep but in reducing stress[11], acting as a pointer to how Revival can do a lot more for users than simply help with sleep.

5-HTP

Another amino acid, 5-HTP is used by the body to produce serotonin, a chemical that is important for a variety of purposes with low levels linked to depression[12], anxiety, weight gain and poor sleep.[13][14][15]

5-HTP is unique as far as we know by being found in supplements designed to help reduce bodyfat (where it works by increasing satiety) as well as those designed for improved sleep like Revival. It is another example of how Revival can do more for the user than simply help improve sleep quality.

Safranal – A Wonder Compound

So far the ingredients we have covered have not been particularly unique but at this point we turn to arguably the most interesting of all the ingredients found in Revival in Safranal, an ingredient which is highly likely to be new to anyone reading this as well as being pretty much unique to Hydrapharm.

Safranal is an organic compound isolated from the herb saffron, a common ingredient in South Asian cuisine and noted for its distinctive aroma. Before we discuss its research background, the reason it is extremely difficult if not impossible to find in other supplements is that it is actually an oil and so pretty much impossible to encapsulate let alone combine with other ingredients that come in powder form.

Hydrapharm have developed a technique to make safranal work as a dry compound by bonding it with a cyclodextrin which has the additional benefit of making the safranal much more potent! Apparently, this was just as much of a stumbling block to the creation of Revival as any of the research, sourcing and testing involved in making the product. 

Safranal’s Effects on Sleep, Anxiety and Mood

We have spoken already about the importance of NREM sleep, and perfectly on cue, we find safranal has been studied for just this quality with a study showing it both increased the duration of NREM sleep, reduced sleep latency and enhanced the delta power activity of NREM sleep. In layman’s terms it not only reduced the time to fall asleep and increased the time spent in the most important phase of sleep but increased the quality of NREM sleep itself![16]

That’s not all as safranal has also been shown to improve both sleep quality and reduce anxiety in other studies[17][18], with these two effects highly correlated as anxiety is almost always the reason why it can be difficult to fall asleep and stay asleep. While anxiety can sometimes have trivial causes like overconsumption of stimulants, more often than not it is correlated to other mood disturbances so you’d expect safranal to address more than anxiety if it was to work well over a long period of time.

Indeed, there is a huge amount of research showing it does just that with research supporting its ability to improve serotonin and dopamine[19], and be as effective, if not more effective, than prescription anti-depressants[20][21]such as fluoxetine (although nobody using those should consider using Revival without first discussing it with their doctor). 

Safranal benefits extend yet further to support not only mood but boost focus and attention[22]which may seem paradoxical for a sleep aid but underlines that Revival could also be used as a supplement at a lower dose during the day in much the same way as CBD Oil can be used both for focus and for sleep.

Safranal Effects on General Health

You will see why we are terming it a wonder compound when you take a look at its effects outside of its impact on sleep related functions.  Safranal has been shown to confer the following health benefits, and indeed this is just a small sample of some of its properties in this area: 

  • Exhibitanti-inflammatory[23]and antioxidant effects[24][25]
  • Reduce opioid related withdrawal symptoms[26]
  • Improve sexual function parameters in both sexes[27][28][29]
  • Enhance cognitive ability[30][31]
  • Reduce PMS symptoms[32][33]
  • Exhibit anti-bacterial[34]and anti-viral properties[35]
  • Improve digestive tract symptoms[36]
  • Reduce pain[37][38]

  • Improve poor [39]eyesight related symptoms[40]
  • Exhibits anti-aging[41][42]and immunity benefits[43]
  • Protect the liver (particularly useful for those using prohormones and the like)[44][45]

When you read a laundry list of improvements like this you can perhaps understand what we discussed when we said we noticed benefits other than the expected ones on sleep. However, it is not just general health improvements we noted.

Safranal Benefits for Athletes and Bodybuilders

When it comes to ergogenics, substances that improve physical performance, sceptics may allow creatine as an example of a supplement with extensive research supporting its use, and maybe a few others like beta-alanine and citrulline malate but we frequently hear the refrain of there being insufficient studies on humans, or on those engaged in physical exercise.

Therefore, when Hydrapharm showed us the research on safranal’s abilities to improve performance we were very surprised and even moreso from studies showing benefits from as little as a single dose[46], something even creatine will not do.

Among its proven benefits, safranal has been shown to improve exercise performance[47][48], improve endurance capacity as well as exhibit anti-oxidant, and anti-inflammatory effects[49], and reduce delayed onset muscle soreness[50]

What’s more, it has also been shown to significantly increase testosterone levels in young men[51]with yet another study showing the same result for testosterone levels but which also documented an increase in both growth hormone and IGF-1 levels, two peptides that are notoriously difficult to increase naturally butwhich both saw significant improvements, once again in a group of young men who many will regard as the gold standard for studies like this.[52]

Last but not least, safranal has also been shown to help support fat loss with multiple studies showing it can reduce snacking and increase satiety[53], help lower blood glucose[54][55]and thus increase the use of bodyfat as a fuel source, as well as show anti-lipogenic properties[56][57].

This is not even an exhaustive list of benefits but to conclude the section of safranal, we think Hydrapharm have unearthed an absolute diamond of an ingredient and what’s more, their version is more potent than the ones used in most of the research meaning you can expect even greater benefits!

Emoxypine

The next star ingredient in the Revival formula is Emoxypine which of course is also available as a standalone ingredient under the Hydrapharm product line. As we have already discussed it on the product page as well as written an articleon it, we will keep it brief here by saying that not only has it been shown to reduce anxiety and thus help with sleeping[58][59]but that you can read real user reviews on the product page which should help underline its real world potential for users looking for a general purpose nootropic.

2-Bromomelatonin

Finally we come to the final ingredient in Revival and this is another unique one. As you may gather from the name, it plays a role in the regulation of melatonin, which is arguably the most important factor in ensuring sleep quality. 

Melatonin is produced naturally by the body with levels increasing once night falls and you put away any screens you may have been viewing. With light reducing melatonin levels this is one reason Hydrapharm have stated on the label that users should avoid bright light at bedtime when using Revival.

While melatonin supplementation helps with sleep onset it is probably more widely used as a means to combat jet-lag due to its importance in regulating the sleep-wake cycle. As beneficial as melatonin is, it has mixed research support with many users tending to find it does not really do much by itself.

2-Bromomelatonin though is not the same thing as melatonin itself as it has been shown to be ten times more potent than melatonin itself while significantly potentiating the effects of GABA which is produced when we sleep[60]. This makes it an altogether more valuable ingredient than melatonin itself and yet another first from Hydrapharm in its introduction in Revival.

Summary

By now you can see that in formulating Revival the way they have, Hydrapharm have exceeded themselves and produced a supplement which not only beats any other in the sleep aid category, but goes much further still in having an effect on other areas you will find beneficial in your fitness journey.


[1 Magnesium in man: implications for health and disease.

de Baaij JH1, Hoenderop JG1, Bindels RJ1.

[2 Effect of magnesium supplementation on blood pressure: a meta-analysis.

Kass L1, Weekes J, Carpenter L.

[3 Effects of oral magnesium supplementation on glycaemic control in Type 2 diabetes: a meta-analysis of randomized double-blind controlled trials.

Song Y1, He K, Levitan EB, Manson JE, Liu S.

[4 Long-term HRV analysis shows stress reduction by magnesium intake.

Wienecke E1, Nolden C2.

[5 Dietary factors and fluctuating levels of melatonin.

Peuhkuri K1, Sihvola N, Korpela R.

[6 Benzodiazepine/GABA(A) receptors are involved in magnesium-induced anxiolytic-like behavior in mice.

Poleszak E1.

[7 GABA mechanisms and sleep.

Gottesmann C1.

[8 Valerian for Sleep: A Systematic Review and Meta-Analysis

Stephen Bent, MD,a,b Amy Padula, MS,b Dan Moore, PhD,cMichael Patterson, MS,a and  Wolf Mehling, MDa

[9 https://www.mayoclinic.org/diseases-conditions/insomnia/expert-answers/valerian/faq-20057875

[10 GABA and l-theanine mixture decreases sleep latency and improves NREM sleep

Suhyeon Kim,a,* Kyungae Jo,a,* Ki-Bae Hong,b Sung Hee Han,c and Hyung Joo Suhd

[11 Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.

Hidese S, et al. Nutrients. 2019.

[12 Insomnia, serotonin and depression.

Vashadze ShV.

[13 Brain serotonin, carbohydrate-craving, obesity and depression.

Wurtman RJ1, Wurtman JJ.

[14 Therapeutic Symptomatic Strategies in the Parasomnias.

Manni R1, Toscano G2, Terzaghi M2.

[15 Two combined amino acids promote sleep activity in caffeine-induced sleepless model systems

Ki-Bae Hong,1 Yooheon Park,2 and Hyung Joo Suhcorresponding author3

[16 Safranal enhances non-rapid eye movement sleep in pentobarbital-treated mice. CNS Neurosci Ther.

Liu Z, Xu XH, Liu TY, Hong ZY, Urade Y, Huang ZL, et al

[17 Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice.

Hosseinzadeh H1, Noraei NB.

[18 Effects of Saffron on Cognition, Anxiety, and Depression in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Double-Blind Placebo-Controlled Trial.

Moazen-Zadeh E1, Abbasi SH2, Safi-Aghdam H1, Shahmansouri N2, Arjmandi-Beglar A2, Hajhosseinn Talasaz A2, Salehiomran A2, Forghani S3, Akhondzadeh S1.

[19 Saffron (Crocus sativus L.): As an Antidepressant

Mohammad J. Siddiqui, Mohammed S. M. Saleh, Siti N. B. Binti Basharuddin, Siti H. Binti Zamri, Mohd H. bin Mohd Najib, Muhammad Z. bin Che Ibrahim, Nur A. binti Mohd Noor, Hanin N. Binti Mazha, Norazian Mohd Hassan, and Alfi Khatib

[20 Comparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial.

Kashani L, Eslatmanesh S, Saedi N, Niroomand N, Ebrahimi M, Hosseinian M, Foroughifar T, Salimi S, Akhondzadeh S.

[21 Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials

Heather Ann Hausenblas, Ph.D., Debbie Saha, B.S., Pamela Jean Dubyak, M.S., and Stephen Douglas Anton, Ph.D.

[22 The effects of Crocus sativus (saffron) and its constituents on nervous system: A review

Mohammad Reza Khazdair, Mohammad Hossein Boskabady, Mahmoud Hosseini,* Ramin Rezaee, and Aristidis M. Tsatsakis

[23 Antinociceptive and anti-inflammatory effects of Crocus sativus L stigma and petal extracts in mice. BMC Pharmacol. 2002;15:2–7.

Hosseinzadeh H, Younesi HM.

[24 Antioxidant activity of aqueous and ethanolic extracts of Crocus sativus L stigma and its bioactive constituent, crocin and safranal. Pharmacogn Mag. 2009;5:419–424.

Hosseinzadeh H, Shamsaie F, Soghra M.

[25 Radical scavenging activity of Crocus sativus L extract and its bioactive constituents. Phytother Res. 2005;19:997–1000. 

Assimopoulou AN, Sinakos Z, Papageorgiou

[26 Effect of Crocus sativus L (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice. Phytother Res . 2010;24:726–730.

Hosseinzadeh H, Jahanian Z.

[27 The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. Phytomedicine . 2008;15:491–495.

Hosseinzadeh H, Ziaee T, Sadeghi A.

[28 Evaluation of Crocus sativus L (saffron) on male erectile dysfunction

Shamsa A, Hosseinzadeh H, Molaei M, Shakeri MT, Rajabi O

[29 Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study.

Kashani L, Raisi F, Saroukhani S, Sohrabi H, Modabbernia A, Nasehi AA, Jamshidi A, Ashrafi M, Mansouri P, Ghaeli P, Akhondzadeh S.

[30 Effects of saffron (Crocus sativus L) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phytother Res . 2012;26:381–386.

Hosseinzadeh H, Sadeghnia HR, Ghaeni FA, Motamedshariaty VS, Mohajeri SA.

[31 Effects of Crocus sativus stigma extract and its constituents, crocin and safranal, on intact memory and scopolamine induced learning deficits in rats performing the Morris water maze task. J Med Plants 

H Hosseinzadeh, T Ziaei

[32 Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial.

Agha-Hosseini M1, Kashani L, Aleyaseen A, Ghoreishi A, Rahmanpour H, Zarrinara AR, Akhondzadeh S.

[33 The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial.

Nahid K, Fariborz M, Ataolah G, Solokian S.

[34 Bactericidal effect of saffron (Crocus sativus L) on Salmonella enterica during storage. Food Control. 

Pintado C, Miguel A, Acevedo O, Nozal L, Novella JL, Rotger R.

[35 Antiviral Effects of Saffron and its Major Ingredients.

Soleymani S, Zabihollahi R, Shahbazi S, Bolhassani A.

[36 Therapeutic effects of saffron (Crocus sativus L.) in digestive disorders: a review

Alireza Rezaee Khorasany and Hossein Hosseinzadeh

[37 An overview on saffron, phytochemicals, and medicinal properties

Ahmad Reza Gohari, Soodabeh Saeidnia, and Mahdie Kourepaz Mahmoodabadi

[38 Effects of Saffron (Crocus sativus L.) Stigma Extract and its Active Constituent Crocin on Neuropathic Pain Responses in a Rat Model of Chronic Constriction Injury

Hossein Ali Safakhah, Tahereh Taghavi, Ali Rashidy-Pour, Abbas Ali Vafaei, Mina Sokhanvar, Narges Mohebbi, and Mostafa Rezaei-Tavirani

[39 Effects of crocin analogs on ocular blood flow and retinal function.

Xuan B, Zhou YH, Li N, Min ZD, Chiou GC.

[40 Saffron therapy for the treatment of mild/moderate age-related macular degeneration: a randomised clinical trial.

Broadhead GK, Grigg JR, McCluskey P, Hong T, Schlub TE, Chang AA

[41 Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial.

Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi A.

[42 Effects of Crocus sativus Stigma Extract and its Constituents, Crocin and Safranal, on Intact Memory and Scopolamine-Induced Learning Deficits in Rats Performing the Morris Water Maze Task

H Hosseinzadeh, T Ziaei

[43 Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial.

Kianbakht S, Ghazavi A.

[44 Hepatoprotective effect of Crocus sativus (saffron) petals extract against acetaminophen toxicity in male Wistar rats

Arash Omidi, Narges Riahinia, Mohammad Bagher Montazer Torbati, and Mohammad-Ali Behdani

[45 Saffron as an antidote or a protective agent against natural or chemical toxicities

Bibi Marjan Razavi and Hossein Hosseinzadeh

[46 Effect of a single dose of Saffron (Crocus sativus) on anaerobic power in young active males

W.Abassi, N.Ouerghi, N.Jebabli, M.Feki, A.Bouassida

[47 Ergogenic effect of 5 days supplementation with Saffron on exhaustive exercise

Abbas Meamarbashi; Seyed Ali Abbaszadeh

[48 Potential Ergogenic Effects of Saffron.

Meamarbashi A, Rajabi A.

[49 Saffron enhanced mitochondrial biogenesis, decreased oxidative stress, inflammation, and modulated metabolic biomarkers in exercised rats in below:

Effect of saffron (Crocus sativus L.) and endurance training on mitochondrial biogenesis, endurance capacity, inflammation, antioxidant, and metabolic biomarkers in Wistar rats 

Maryam Akbari‐Fakhrabadi,  Mohammad Najafi,  Soudabehsadat Mortazavian,  Mahboobeh Rasouli, Amir‐Hossein Memari,  Farzad Shidfar,

[50 Preventive Effects of 10-Day Supplementation With Saffron and Indomethacin on the Delayed-Onset Muscle Soreness

Meamarbashi, Abbas PhD; Rajabi, Ali MSc

[51 Interactive Effect of Saffron Supplementation and Resistance Training on serum levels of sex hormones in young men

Abbas Ali Gaeini , Parisa Pournemati, Babak Hooshmand moghadam  

[52 Effect of Complementary Saffron and Resistance Training on Serum Levels of Growth Hormone, Insulin-like Growth Factor-1 and Testosterone in Young Men

Babak Hooshmand moghadam, Abbas Ali Gaeini Dr

[53] Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women.

Gout B, Bourges C, Paineau-Dubreuil S.

[54 Saffron with resistance exercise improves diabetic parameters through the GLUT4/AMPK pathway in-vitro and in-vivo

Firouzeh Dehghan, Fatemeh Hajiaghaalipour, Ashril Yusof, Sekaran Muniandy, Seyed Ali Hosseini, Sedigheh Heydari, Landa Zeenelabdin Ali Salim, and Mohammad Ali Azarbayjanib

[55 Anti-hyperglycemic effects of saffron and its active constituents, crocin and safranal, in alloxan-induced diabetic rats. J Med Plants . 2011;10:82–89. 

Kianbakht S, Hajiaghaee R.

[56 Saffron: A Natural Potent Antioxidant as a Promising Anti-Obesity Drug

Maryam Mashmoul, Azrina Azlan, Huzwah Khaza’ai, Barakatun Nisak Mohd Yusof, and  Sabariah Mohd Noor

[57 Mechanism of hypolipidemic effect of crocin in rats: Crocin inhibits pancreatic lipase.Eur. J. Pharmacol. 2006;543:116–122

Sheng L., Qian Z., Zheng S., Xi L.

[58 Anxiolytic and Antidepressant Actions of Emoxypine, Reamberin, and Mexidol in Experimental Diabetes Mellitus

A. Volchegorskii, I. Yu. Miroshnichenko, L. M. Rassokhina, R. M. Faizullin & K. E. Pryakhina

[59 Anxiolytic and Antidepressant Actions of 3-Hydroxypyridine and Succinic Acid Derivatives in Alloxan Diabetes

I. A. Volchegorskii Yu. Miroshnichenko. M. Rassokhina. M. Faizullin. E. Pryakhina. V. Kalugina

[60 2-Bromomelatonin: synthesis and characterization of a potent melatonin agonist.

Duranti E1, Stankov B, Spadoni G, Duranti A, Lucini V, Capsoni S, Biella G, Fraschini F.

100%
 3 REVIEWS
Excellent

Only used it a couple of times but I slept over at my mother in laws house where they don’t have any curtains which means I always sleep poorly but when I used this I slept great and zero grogginess.

Effective despite my reservations

Didn’t think a sleep aid without gaba or Phenibut would do much but this works very well with consistent results even with regular use (unlike the ingredients above)

Awesome

I struggle to sleep and have tried loads of different products like ZMA, Resurrect, diphenhydramine and Night Nurse.rnrnI was recommended Revival by my friend who gave me a 3 capsule sample. I took it half an hour before going to sleep, and was zonked out within 10 minutes of getting into bed. (It normally takes me about 30-40mins to nod off). I slept solidly through the night (normally tend to wake up at least once or twice throughout the night). Woke up after 8 hours feeling completely refreshed, no groggy feeling like I have had when trying other products. I’ve been using now for approximately 3 weeks, and had really consistent results.

Hydrapharm Revival 30 servings - Improves sleep and mood
Predator Review
Predator Nutrition Revival Review

All-Purpose Supplement for General Health

Hydrapharm have built a reputation for innovation that is second to none in the sports nutrition industry. However, more than innovation they have become industry leaders for products that deliver and deliver big whether the goal is better performance, greater muscle mass, faster recovery, or potent nootropics that you notice from day one.

Their latest product, Revival, falls into the latter category albeit a nootropic that is less about focus and productivity, and more about relaxation and enhancing sleep quality. However, even that underplays the potential benefits since both an understanding from using it and a deep dive of the research behind its ingredients illustrates that Revival is far more than a sleep aid and instead offers a range of benefits that makes it much more akin to the health and wellbeing version of an all-in-one supplement like Quantum.

The Problems with Existing Sleep Aids

The sleep aid category is broadly split into three types of products.

In the first are highly effective ingredients which are both illegal in the EU, but which also have innate issues with them such as rapid habituation that leads to ever greater doses and decreasing effectiveness.

At the extreme end, they include products such as Phenibut which are only possible to be used once or twice a week to avoid both side effects and to actually be effective still. Usually comprising GABA analogues, this class of product are only really useful for those with periodic issues with falling asleep and are a very bad choice for those with frequent issues with falling and staying asleep.

In the second class, are sleep aids you can commonly find sold in health shops, or supermarkets. Containing a range of herbs or minerals, these are generally effective only for those with occasional sleep problems and fail to help anyone with more chronic sleep issues, especially the type of wired individual who finds it a constant struggle to quieten their mind when going to bed. At best, these types of ingredients can provide a useful adjunct to a sleep aid but are not very effective by themselves.

In the final class, we have pharmaceuticals which tend to consist of benzodiazepenes, antihistamines and Z-class drugs such as Zolpidem and Zopiclone. While they will help users to fall asleep and stay asleep when used occasionally they are also rapidly habituated to, have a range of deleterious side effects, and arguably worst of all, are not much good at all due to their failing to deliver the non-rapid eye movement (NREM) sleep that is critical for improving sleep quality. Instead, by taking a sledgehammer approach, you often find yourself more tired and groggy the day after and these all tend to stimulate appetite strongly – the very last thing most athletes need.

Revival - The Best Sleep Aid Designed 

Given the issues with existing sleep aid products, Hydrapharm remarked to us that Revival proved to be the most difficult product they had ever created, both in finding ingredients that avoid the issues with existing sleep aids and to do so with no dimunition in effect over the long term. However, they told us that extensive testing with Revival made them confident that it would not only prove to be effective but to actually work better the longer it was used.

This seemed too good to be true but our own experience with using it appeared to back up their claims, with our users finding that it both helped with sleep onset, maintaining sleep through the night without the periods of wakefulness that can plague other sleep aids, and that not only did it prove effective with repeated use, but it conferred other benefits we had not even expected but are no surprise when you see some of the benefits associated with some of the ingredients in Revival with safranal and emoxypine being particularly noteworthy in this regard.

Once we look at the data behind the ingredients, it becomes apparent that this was no fluke but a consequence of a combination of ingredients with extensive research behind them.

Revival Ingredient Overview

Revival contains seven different ingredients which encompasses both some we have seen before, and then a few which we’ve not encountered before in a sleep aid.

Magnesium

Magnesium is a mineral which plays a key role in a huge range of bodily processes, including everything from regulating muscular contractions,[1]lowering blood pressure[2]and improving blood sugar control[3]to name just a few that can help athletes who are more likely than not to be deficient in this key mineral. 

However, it is magnesium’s effects on insomnia that merit its inclusion within Revival. Studies show magnesium can help adults fall asleep faster and improve both sleep quality and reduce insomnia symptoms,[4]as well as regulate your body’s sleep-wake cycle[5]and bind to GABA receptors which are crucial for calming nerve activity that can otherwise negatively effect your ability to sleep.[6][7]

Magnesium is one of the ingredients that are hardly new to a sleep aid but an often overlooked component of using this ingredient is the type of magnesium used. Not only do magnesium supplements vary widely in their degree of absorption but the cheaper forms prevalent in many supplements can cause gastric distress.

Magnesium Bisglycinate, the form found in Revival is both the best type of magnesium from an absorption standpoint while also avoiding many of the side effects seen with other forms of magnesium.

Valerian

Valerian is a herb which has been used for centuries as a traditional sleep aid and is a no-brainer being both safe and effective with a meta-analysis of 16 studies comfirming its ability to improve sleep quality.[8][9]

Valerian is certainly not a new ingredient but its inclusion within Revival is to help ensure that the formula is not reliant on any one ingredient but instead ensuring sleep is driven through a variety of mechanisms rather than relying on any single ingredient.

L-Theanine

Theanine is an amino acid which has been long overlooked by athletes but has lately been used increasingly as a way of helping to provide relaxation, with one of its uses being paired with stimulants to help manage the anxiety stimulants can sometimes cause.

While its use as a standalone sleep aid is unlikely to deliver many benefits, its inclusion within Revival is due to theanine’s ability to help relax the mind such that your brain switches off at night as well as its ability to both decrease sleep latency and improve the all-important NREM sleep that is linked to improved sleep quality, at least when paired with supporting ingredients that have a sedating effect.[10]

Additionally, research shows that theanine has a positive effect not only on sleep but in reducing stress[11], acting as a pointer to how Revival can do a lot more for users than simply help with sleep.

5-HTP

Another amino acid, 5-HTP is used by the body to produce serotonin, a chemical that is important for a variety of purposes with low levels linked to depression[12], anxiety, weight gain and poor sleep.[13][14][15]

5-HTP is unique as far as we know by being found in supplements designed to help reduce bodyfat (where it works by increasing satiety) as well as those designed for improved sleep like Revival. It is another example of how Revival can do more for the user than simply help improve sleep quality.

Safranal – A Wonder Compound

So far the ingredients we have covered have not been particularly unique but at this point we turn to arguably the most interesting of all the ingredients found in Revival in Safranal, an ingredient which is highly likely to be new to anyone reading this as well as being pretty much unique to Hydrapharm.

Safranal is an organic compound isolated from the herb saffron, a common ingredient in South Asian cuisine and noted for its distinctive aroma. Before we discuss its research background, the reason it is extremely difficult if not impossible to find in other supplements is that it is actually an oil and so pretty much impossible to encapsulate let alone combine with other ingredients that come in powder form.

Hydrapharm have developed a technique to make safranal work as a dry compound by bonding it with a cyclodextrin which has the additional benefit of making the safranal much more potent! Apparently, this was just as much of a stumbling block to the creation of Revival as any of the research, sourcing and testing involved in making the product. 

Safranal’s Effects on Sleep, Anxiety and Mood

We have spoken already about the importance of NREM sleep, and perfectly on cue, we find safranal has been studied for just this quality with a study showing it both increased the duration of NREM sleep, reduced sleep latency and enhanced the delta power activity of NREM sleep. In layman’s terms it not only reduced the time to fall asleep and increased the time spent in the most important phase of sleep but increased the quality of NREM sleep itself![16]

That’s not all as safranal has also been shown to improve both sleep quality and reduce anxiety in other studies[17][18], with these two effects highly correlated as anxiety is almost always the reason why it can be difficult to fall asleep and stay asleep. While anxiety can sometimes have trivial causes like overconsumption of stimulants, more often than not it is correlated to other mood disturbances so you’d expect safranal to address more than anxiety if it was to work well over a long period of time.

Indeed, there is a huge amount of research showing it does just that with research supporting its ability to improve serotonin and dopamine[19], and be as effective, if not more effective, than prescription anti-depressants[20][21]such as fluoxetine (although nobody using those should consider using Revival without first discussing it with their doctor). 

Safranal benefits extend yet further to support not only mood but boost focus and attention[22]which may seem paradoxical for a sleep aid but underlines that Revival could also be used as a supplement at a lower dose during the day in much the same way as CBD Oil can be used both for focus and for sleep.

Safranal Effects on General Health

You will see why we are terming it a wonder compound when you take a look at its effects outside of its impact on sleep related functions.  Safranal has been shown to confer the following health benefits, and indeed this is just a small sample of some of its properties in this area: 

  • Exhibitanti-inflammatory[23]and antioxidant effects[24][25]
  • Reduce opioid related withdrawal symptoms[26]
  • Improve sexual function parameters in both sexes[27][28][29]
  • Enhance cognitive ability[30][31]
  • Reduce PMS symptoms[32][33]
  • Exhibit anti-bacterial[34]and anti-viral properties[35]
  • Improve digestive tract symptoms[36]
  • Reduce pain[37][38]

  • Improve poor [39]eyesight related symptoms[40]
  • Exhibits anti-aging[41][42]and immunity benefits[43]
  • Protect the liver (particularly useful for those using prohormones and the like)[44][45]

When you read a laundry list of improvements like this you can perhaps understand what we discussed when we said we noticed benefits other than the expected ones on sleep. However, it is not just general health improvements we noted.

Safranal Benefits for Athletes and Bodybuilders

When it comes to ergogenics, substances that improve physical performance, sceptics may allow creatine as an example of a supplement with extensive research supporting its use, and maybe a few others like beta-alanine and citrulline malate but we frequently hear the refrain of there being insufficient studies on humans, or on those engaged in physical exercise.

Therefore, when Hydrapharm showed us the research on safranal’s abilities to improve performance we were very surprised and even moreso from studies showing benefits from as little as a single dose[46], something even creatine will not do.

Among its proven benefits, safranal has been shown to improve exercise performance[47][48], improve endurance capacity as well as exhibit anti-oxidant, and anti-inflammatory effects[49], and reduce delayed onset muscle soreness[50]

What’s more, it has also been shown to significantly increase testosterone levels in young men[51]with yet another study showing the same result for testosterone levels but which also documented an increase in both growth hormone and IGF-1 levels, two peptides that are notoriously difficult to increase naturally butwhich both saw significant improvements, once again in a group of young men who many will regard as the gold standard for studies like this.[52]

Last but not least, safranal has also been shown to help support fat loss with multiple studies showing it can reduce snacking and increase satiety[53], help lower blood glucose[54][55]and thus increase the use of bodyfat as a fuel source, as well as show anti-lipogenic properties[56][57].

This is not even an exhaustive list of benefits but to conclude the section of safranal, we think Hydrapharm have unearthed an absolute diamond of an ingredient and what’s more, their version is more potent than the ones used in most of the research meaning you can expect even greater benefits!

Emoxypine

The next star ingredient in the Revival formula is Emoxypine which of course is also available as a standalone ingredient under the Hydrapharm product line. As we have already discussed it on the product page as well as written an articleon it, we will keep it brief here by saying that not only has it been shown to reduce anxiety and thus help with sleeping[58][59]but that you can read real user reviews on the product page which should help underline its real world potential for users looking for a general purpose nootropic.

2-Bromomelatonin

Finally we come to the final ingredient in Revival and this is another unique one. As you may gather from the name, it plays a role in the regulation of melatonin, which is arguably the most important factor in ensuring sleep quality. 

Melatonin is produced naturally by the body with levels increasing once night falls and you put away any screens you may have been viewing. With light reducing melatonin levels this is one reason Hydrapharm have stated on the label that users should avoid bright light at bedtime when using Revival.

While melatonin supplementation helps with sleep onset it is probably more widely used as a means to combat jet-lag due to its importance in regulating the sleep-wake cycle. As beneficial as melatonin is, it has mixed research support with many users tending to find it does not really do much by itself.

2-Bromomelatonin though is not the same thing as melatonin itself as it has been shown to be ten times more potent than melatonin itself while significantly potentiating the effects of GABA which is produced when we sleep[60]. This makes it an altogether more valuable ingredient than melatonin itself and yet another first from Hydrapharm in its introduction in Revival.

Summary

By now you can see that in formulating Revival the way they have, Hydrapharm have exceeded themselves and produced a supplement which not only beats any other in the sleep aid category, but goes much further still in having an effect on other areas you will find beneficial in your fitness journey.


[1 Magnesium in man: implications for health and disease.

de Baaij JH1, Hoenderop JG1, Bindels RJ1.

[2 Effect of magnesium supplementation on blood pressure: a meta-analysis.

Kass L1, Weekes J, Carpenter L.

[3 Effects of oral magnesium supplementation on glycaemic control in Type 2 diabetes: a meta-analysis of randomized double-blind controlled trials.

Song Y1, He K, Levitan EB, Manson JE, Liu S.

[4 Long-term HRV analysis shows stress reduction by magnesium intake.

Wienecke E1, Nolden C2.

[5 Dietary factors and fluctuating levels of melatonin.

Peuhkuri K1, Sihvola N, Korpela R.

[6 Benzodiazepine/GABA(A) receptors are involved in magnesium-induced anxiolytic-like behavior in mice.

Poleszak E1.

[7 GABA mechanisms and sleep.

Gottesmann C1.

[8 Valerian for Sleep: A Systematic Review and Meta-Analysis

Stephen Bent, MD,a,b Amy Padula, MS,b Dan Moore, PhD,cMichael Patterson, MS,a and  Wolf Mehling, MDa

[9 https://www.mayoclinic.org/diseases-conditions/insomnia/expert-answers/valerian/faq-20057875

[10 GABA and l-theanine mixture decreases sleep latency and improves NREM sleep

Suhyeon Kim,a,* Kyungae Jo,a,* Ki-Bae Hong,b Sung Hee Han,c and Hyung Joo Suhd

[11 Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.

Hidese S, et al. Nutrients. 2019.

[12 Insomnia, serotonin and depression.

Vashadze ShV.

[13 Brain serotonin, carbohydrate-craving, obesity and depression.

Wurtman RJ1, Wurtman JJ.

[14 Therapeutic Symptomatic Strategies in the Parasomnias.

Manni R1, Toscano G2, Terzaghi M2.

[15 Two combined amino acids promote sleep activity in caffeine-induced sleepless model systems

Ki-Bae Hong,1 Yooheon Park,2 and Hyung Joo Suhcorresponding author3

[16 Safranal enhances non-rapid eye movement sleep in pentobarbital-treated mice. CNS Neurosci Ther.

Liu Z, Xu XH, Liu TY, Hong ZY, Urade Y, Huang ZL, et al

[17 Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice.

Hosseinzadeh H1, Noraei NB.

[18 Effects of Saffron on Cognition, Anxiety, and Depression in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Double-Blind Placebo-Controlled Trial.

Moazen-Zadeh E1, Abbasi SH2, Safi-Aghdam H1, Shahmansouri N2, Arjmandi-Beglar A2, Hajhosseinn Talasaz A2, Salehiomran A2, Forghani S3, Akhondzadeh S1.

[19 Saffron (Crocus sativus L.): As an Antidepressant

Mohammad J. Siddiqui, Mohammed S. M. Saleh, Siti N. B. Binti Basharuddin, Siti H. Binti Zamri, Mohd H. bin Mohd Najib, Muhammad Z. bin Che Ibrahim, Nur A. binti Mohd Noor, Hanin N. Binti Mazha, Norazian Mohd Hassan, and Alfi Khatib

[20 Comparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial.

Kashani L, Eslatmanesh S, Saedi N, Niroomand N, Ebrahimi M, Hosseinian M, Foroughifar T, Salimi S, Akhondzadeh S.

[21 Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials

Heather Ann Hausenblas, Ph.D., Debbie Saha, B.S., Pamela Jean Dubyak, M.S., and Stephen Douglas Anton, Ph.D.

[22 The effects of Crocus sativus (saffron) and its constituents on nervous system: A review

Mohammad Reza Khazdair, Mohammad Hossein Boskabady, Mahmoud Hosseini,* Ramin Rezaee, and Aristidis M. Tsatsakis

[23 Antinociceptive and anti-inflammatory effects of Crocus sativus L stigma and petal extracts in mice. BMC Pharmacol. 2002;15:2–7.

Hosseinzadeh H, Younesi HM.

[24 Antioxidant activity of aqueous and ethanolic extracts of Crocus sativus L stigma and its bioactive constituent, crocin and safranal. Pharmacogn Mag. 2009;5:419–424.

Hosseinzadeh H, Shamsaie F, Soghra M.

[25 Radical scavenging activity of Crocus sativus L extract and its bioactive constituents. Phytother Res. 2005;19:997–1000. 

Assimopoulou AN, Sinakos Z, Papageorgiou

[26 Effect of Crocus sativus L (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice. Phytother Res . 2010;24:726–730.

Hosseinzadeh H, Jahanian Z.

[27 The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. Phytomedicine . 2008;15:491–495.

Hosseinzadeh H, Ziaee T, Sadeghi A.

[28 Evaluation of Crocus sativus L (saffron) on male erectile dysfunction

Shamsa A, Hosseinzadeh H, Molaei M, Shakeri MT, Rajabi O

[29 Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study.

Kashani L, Raisi F, Saroukhani S, Sohrabi H, Modabbernia A, Nasehi AA, Jamshidi A, Ashrafi M, Mansouri P, Ghaeli P, Akhondzadeh S.

[30 Effects of saffron (Crocus sativus L) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phytother Res . 2012;26:381–386.

Hosseinzadeh H, Sadeghnia HR, Ghaeni FA, Motamedshariaty VS, Mohajeri SA.

[31 Effects of Crocus sativus stigma extract and its constituents, crocin and safranal, on intact memory and scopolamine induced learning deficits in rats performing the Morris water maze task. J Med Plants 

H Hosseinzadeh, T Ziaei

[32 Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial.

Agha-Hosseini M1, Kashani L, Aleyaseen A, Ghoreishi A, Rahmanpour H, Zarrinara AR, Akhondzadeh S.

[33 The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial.

Nahid K, Fariborz M, Ataolah G, Solokian S.

[34 Bactericidal effect of saffron (Crocus sativus L) on Salmonella enterica during storage. Food Control. 

Pintado C, Miguel A, Acevedo O, Nozal L, Novella JL, Rotger R.

[35 Antiviral Effects of Saffron and its Major Ingredients.

Soleymani S, Zabihollahi R, Shahbazi S, Bolhassani A.

[36 Therapeutic effects of saffron (Crocus sativus L.) in digestive disorders: a review

Alireza Rezaee Khorasany and Hossein Hosseinzadeh

[37 An overview on saffron, phytochemicals, and medicinal properties

Ahmad Reza Gohari, Soodabeh Saeidnia, and Mahdie Kourepaz Mahmoodabadi

[38 Effects of Saffron (Crocus sativus L.) Stigma Extract and its Active Constituent Crocin on Neuropathic Pain Responses in a Rat Model of Chronic Constriction Injury

Hossein Ali Safakhah, Tahereh Taghavi, Ali Rashidy-Pour, Abbas Ali Vafaei, Mina Sokhanvar, Narges Mohebbi, and Mostafa Rezaei-Tavirani

[39 Effects of crocin analogs on ocular blood flow and retinal function.

Xuan B, Zhou YH, Li N, Min ZD, Chiou GC.

[40 Saffron therapy for the treatment of mild/moderate age-related macular degeneration: a randomised clinical trial.

Broadhead GK, Grigg JR, McCluskey P, Hong T, Schlub TE, Chang AA

[41 Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial.

Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi A.

[42 Effects of Crocus sativus Stigma Extract and its Constituents, Crocin and Safranal, on Intact Memory and Scopolamine-Induced Learning Deficits in Rats Performing the Morris Water Maze Task

H Hosseinzadeh, T Ziaei

[43 Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial.

Kianbakht S, Ghazavi A.

[44 Hepatoprotective effect of Crocus sativus (saffron) petals extract against acetaminophen toxicity in male Wistar rats

Arash Omidi, Narges Riahinia, Mohammad Bagher Montazer Torbati, and Mohammad-Ali Behdani

[45 Saffron as an antidote or a protective agent against natural or chemical toxicities

Bibi Marjan Razavi and Hossein Hosseinzadeh

[46 Effect of a single dose of Saffron (Crocus sativus) on anaerobic power in young active males

W.Abassi, N.Ouerghi, N.Jebabli, M.Feki, A.Bouassida

[47 Ergogenic effect of 5 days supplementation with Saffron on exhaustive exercise

Abbas Meamarbashi; Seyed Ali Abbaszadeh

[48 Potential Ergogenic Effects of Saffron.

Meamarbashi A, Rajabi A.

[49 Saffron enhanced mitochondrial biogenesis, decreased oxidative stress, inflammation, and modulated metabolic biomarkers in exercised rats in below:

Effect of saffron (Crocus sativus L.) and endurance training on mitochondrial biogenesis, endurance capacity, inflammation, antioxidant, and metabolic biomarkers in Wistar rats 

Maryam Akbari‐Fakhrabadi,  Mohammad Najafi,  Soudabehsadat Mortazavian,  Mahboobeh Rasouli, Amir‐Hossein Memari,  Farzad Shidfar,

[50 Preventive Effects of 10-Day Supplementation With Saffron and Indomethacin on the Delayed-Onset Muscle Soreness

Meamarbashi, Abbas PhD; Rajabi, Ali MSc

[51 Interactive Effect of Saffron Supplementation and Resistance Training on serum levels of sex hormones in young men

Abbas Ali Gaeini , Parisa Pournemati, Babak Hooshmand moghadam  

[52 Effect of Complementary Saffron and Resistance Training on Serum Levels of Growth Hormone, Insulin-like Growth Factor-1 and Testosterone in Young Men

Babak Hooshmand moghadam, Abbas Ali Gaeini Dr

[53] Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women.

Gout B, Bourges C, Paineau-Dubreuil S.

[54 Saffron with resistance exercise improves diabetic parameters through the GLUT4/AMPK pathway in-vitro and in-vivo

Firouzeh Dehghan, Fatemeh Hajiaghaalipour, Ashril Yusof, Sekaran Muniandy, Seyed Ali Hosseini, Sedigheh Heydari, Landa Zeenelabdin Ali Salim, and Mohammad Ali Azarbayjanib

[55 Anti-hyperglycemic effects of saffron and its active constituents, crocin and safranal, in alloxan-induced diabetic rats. J Med Plants . 2011;10:82–89. 

Kianbakht S, Hajiaghaee R.

[56 Saffron: A Natural Potent Antioxidant as a Promising Anti-Obesity Drug

Maryam Mashmoul, Azrina Azlan, Huzwah Khaza’ai, Barakatun Nisak Mohd Yusof, and  Sabariah Mohd Noor

[57 Mechanism of hypolipidemic effect of crocin in rats: Crocin inhibits pancreatic lipase.Eur. J. Pharmacol. 2006;543:116–122

Sheng L., Qian Z., Zheng S., Xi L.

[58 Anxiolytic and Antidepressant Actions of Emoxypine, Reamberin, and Mexidol in Experimental Diabetes Mellitus

A. Volchegorskii, I. Yu. Miroshnichenko, L. M. Rassokhina, R. M. Faizullin & K. E. Pryakhina

[59 Anxiolytic and Antidepressant Actions of 3-Hydroxypyridine and Succinic Acid Derivatives in Alloxan Diabetes

I. A. Volchegorskii Yu. Miroshnichenko. M. Rassokhina. M. Faizullin. E. Pryakhina. V. Kalugina

[60 2-Bromomelatonin: synthesis and characterization of a potent melatonin agonist.

Duranti E1, Stankov B, Spadoni G, Duranti A, Lucini V, Capsoni S, Biella G, Fraschini F.

Customer Reviews
100%
 3 REVIEWS
Excellent

Only used it a couple of times but I slept over at my mother in laws house where they don’t have any curtains which means I always sleep poorly but when I used this I slept great and zero grogginess.

Effective despite my reservations

Didn’t think a sleep aid without gaba or Phenibut would do much but this works very well with consistent results even with regular use (unlike the ingredients above)

Awesome

I struggle to sleep and have tried loads of different products like ZMA, Resurrect, diphenhydramine and Night Nurse.rnrnI was recommended Revival by my friend who gave me a 3 capsule sample. I took it half an hour before going to sleep, and was zonked out within 10 minutes of getting into bed. (It normally takes me about 30-40mins to nod off). I slept solidly through the night (normally tend to wake up at least once or twice throughout the night). Woke up after 8 hours feeling completely refreshed, no groggy feeling like I have had when trying other products. I’ve been using now for approximately 3 weeks, and had really consistent results.

Nutrition

Nutrition

Hydrapharm Revival 90 Capsules
Servings per container: 30
Serving size: 3 capsules
  Amount Per Serving %DV**
Revival Proprietary Blend (Magnesium Bisglycinate, Valerian, L-Theanine, Safranal, Emoxypine, 5-HTP, 2-Bromomelatonin) 1326mg
* % DV Is based on a 2000kcal daily diet
† Daily Value is not yet established
Other Ingredients: Gelatin, Rice Flour, Hydroxypropyl Beta Cyclodextrin.
Directions For Use
Take three capsules with a small meal or a drink before bedtime.
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