RAD-140 Review: Benefits, Dosage & Side Effects

RAD-140, also known as Testolone, belongs to a class of compounds called Selective Androgen Receptor Modulators (SARMs). SARMs have gained significant attention in recent years due to their potential to provide the benefits of anabolic steroids, such as increased muscle mass and strength, without the associated side effects [1]. RAD-140 has shown promising results in preclinical studies, suggesting its potential as a therapeutic agent for various conditions, including muscle wasting disorders and age-related muscle loss [2].

The purpose of this article is to provide you with a comprehensive overview of RAD-140, examining its benefits, recommended dosage, potential side effects, and other relevant information. By presenting scientific evidence and user experiences, this article aims to help you make informed decisions about the use of RAD-140, while also highlighting the need for caution when considering its use.

1. What is RAD-140 (Testolone)?
2. Benefits of RAD-140
3. Dosage and Cycle Guidelines
4. Side Effects and Risks
5. Comparison
6. Reviews
7. Where to Buy
8. Conclusion
9. FAQs

 

What is RAD-140 (Testolone)?

RAD-140 is a non-steroidal SARM that was developed by Radius Health, Inc. It is structurally similar to other SARMs, such as LGD-4033 and Ostarine, but with a unique chemical structure that allows for greater selectivity and potency [3]. 

The mechanism of action of RAD-140 involves its ability to selectively bind to androgen receptors in specific tissues, such as muscle and bone, while avoiding other tissues like the prostate, liver, and skin [4]. This selectivity is what sets SARMs apart from traditional anabolic steroids, which tend to have a more widespread effect on the body [5]. By binding to androgen receptors, RAD-140 can stimulate anabolic processes, leading to increased muscle growth and strength.

Preclinical studies have demonstrated the effectiveness of RAD-140 in promoting muscle growth and fat loss. In one study, male rats treated with RAD-140 showed significant increases in lean body mass and muscle strength compared to a control group [6]. 

Despite these promising findings, it is important to note that most of the research on RAD-140 has been conducted in animal models, and human clinical trials are limited [7]. While there is anecdotal evidence from users reporting positive results, such as increased muscle mass and strength, more research is needed to fully understand the effects of RAD-140 in humans and to establish its safety and efficacy [8].

Benefits of RAD-140

Muscle Growth and Strength Enhancement:

 

• Preclinical study on rats showed significant increase in lean body mass compared to the control group [9]
• Selective binding to androgen receptors in muscle tissue stimulates protein synthesis and muscle hypertrophy [10]
• Study found RAD-140 treatment led to increased grip strength in rats, suggesting a positive impact on overall muscle function [11]
• Beneficial for athletes, bodybuilders, and those looking to improve physical performance

 

Fat Loss:

 

• May help increase metabolic rate and improve insulin sensitivity
• Could result in a significant reduction in body fat percentage
• Useful for improving body composition and achieving a leaner physique

 

Potential Therapeutic Applications:

 

• Investigated for treating conditions such as sarcopenia and cachexia [12]
• Selectively targets androgen receptors in muscle tissue to preserve lean body mass and improve physical function
• These conditions are characterized by progressive loss of muscle mass and strength, impacting quality of life and overall health
• Explored as a potential treatment for sarcopenia, the natural loss of muscle mass and strength with age [13]
• May help preserve muscle mass, reduce frailty, improve mobility, and decrease the risk of falls and fractures. 

 

Dosage and Cycle Guidelines

When it comes to determining the appropriate dosage and cycle guidelines for RAD-140, it is important to note that most of the information regarding dosage and cycle lengths is based on anecdotal evidence from users and estimates from preclinical studies. As such, the following guidelines should be considered as general recommendations, and you should always exercise caution and consult with a healthcare professional before starting any new supplement regimen.

The typical dosage range for RAD-140 is between 10-30 mg per day, with most users starting at the lower end of this range and gradually increasing the dose as needed. It is important to start with a lower dose to assess your individual tolerance and response to the compound. Some users may find that they experience significant benefits at lower doses, while others may require higher doses to achieve their desired results.

When considering the duration of a RAD-140 cycle, it is generally recommended to limit the cycle length to 8-12 weeks [14]. This is to minimize the risk of potential side effects and to allow the body sufficient time to recover and restore its natural hormone balance. Longer cycles may be tempting for those of you seeking to maximize their gains, but you can also increase the risk of adverse effects, which may lead to a more pronounced suppression of natural testosterone production.

Side Effects and Risks

While RAD-140 is generally considered to be well-tolerated, it is not without potential side effects and risks. As with any performance-enhancing substance, it is essential to be aware of these potential drawbacks before deciding to use the compound.

One of the most common side effects associated with RAD-140 use is the suppression of natural testosterone production [15]. This occurs because the body recognizes the presence of the exogenous androgen and responds by downregulating its own production of testosterone. The extent of this suppression can vary depending on the dosage and duration of the cycle, as well as individual factors such as age and hormone levels.

Testosterone suppression can lead to a range of symptoms, including fatigue, decreased libido, erectile dysfunction, and mood changes. In some cases, these effects may persist even after the cycle has ended, underscoring the importance of proper PCT to help restore natural hormone balance. Long-term or repeated cycles of RAD-140 without adequate PCT may lead to more severe and persistent hormonal imbalances.

In addition to these specific side effects, RAD-140 may also cause more general adverse reactions, such as headaches, nausea, and changes in blood pressure. These effects are typically mild and transient, but they can be more pronounced in some individuals.

Following a RAD-140 cycle, it is crucial to implement a proper post-cycle therapy (PCT) protocol. PCT is designed to help restore the body's natural testosterone levels, which can become suppressed during the course of a cycle [15]. A typical PCT protocol may last for 4-6 weeks and include the use of aromatase inhibitor like 6-Oxo, testosterone boster like Alchemy and complete products like Fusion Supplements’ Post Cycle Matrix. The specific PCT protocol will depend on individual factors, such as the length and dosage of the RAD-140 cycle, as well as personal response to the compound.

Comparison 

While RAD-140 shares some similarities with other popular SARMs like Ostarine and LGD-4033,such as enhanced muscle growth, strength, and performance, there are also some distinct differences that set RAD-140 apart from them.

Anabolic Effects: RAD-140 has shown to have a higher anabolic effect compared to Ostarine and LGD-4033. In preclinical studies, RAD-140 demonstrates a significant increase in lean body mass and muscle hypertrophy. Ostarine and LGD-4033, while still effective in promoting muscle growth, may not be as potent as RAD-140 in this regard.

Selectivity: RAD-140 exhibits a high degree of selectivity for androgen receptors in muscle and bone tissues, with minimal impact on prostate and sebaceous glands [16]. This selectivity reduces the risk of side effects commonly associated with traditional anabolic steroids. Ostarine and LGD-4033 also display selectivity, but RAD-140's receptor binding affinity and tissue-specific effects may be more pronounced.

Fat Loss: While all three SARMs can potentially aid in fat loss by increasing metabolic rate and improving body composition, RAD-140 may have a slight advantage. Its ability to selectively target androgen receptors in muscle tissue while preserving lean body mass during a caloric deficit could result in more efficient fat loss compared to Ostarine and LGD-4033.

Half-Life: RAD-140 has a longer half-life compared to Ostarine and LGD-4033. While the exact half-life of RAD-140 in humans is not yet known, preclinical studies suggest that it may be around 60 hours. This longer half-life could result in more stable blood levels and potentially require less frequent dosing compared to Ostarine and LGD-4033, which have shorter half-lives of about 24 hours].

Reviews

So far we’ve given you a good deal of information about RAD-140 from a scientific perspective. But what do actual users say about it? Here are some reviews pulled out straight from the Radareal review section:

“It took around 2 weeks to notice an increase in strength. Was also able to reduce rest time in between sets. Would buy again.” ~ Erik V.
“Have used for two weeks and noticed gains in strength and tone. No side effects. Good product.” ~ Steven L.
“It really works! Pumps are real” ~ Eduardo D.
“Put on some serious muscle in just a week of taking this amazing supplement, one at breakfast and the 2nd pill mid afternoon about 2 hours before the workout” ~ S h.

Where To Buy

For those of you who do decide to use RAD-140, it is crucial to obtain the compound from reputable brands and sources. For this reason you can check Augmented Labs Radareal or RAD140 by Olympus Labs as they offer an impressive 90:1 ratio of anabolic to androgenic effects, making it ideal for increasing muscle mass and reducing body fat without the unwanted side effects associated with anabolic steroids, as we’ve already discussed. Users consistently report improved recovery times, rapid muscle growth, increased strength, and enhanced endurance, as evident from the review section:

Radareal is well-suited for advanced trainees seeking a powerful supplement with fewer potential side effects compared to prohormones. By incorporating Radareal into a well-structured 4-6 week cycle, followed by proper PCT and cycle support, you can expect to achieve a more muscular physique and experience significant improvements in strength and power. 

Conclusion

In summary, RAD-140, or Testolone, is a promising selective androgen receptor modulator (SARM) that has shown potential for promoting muscle growth, enhancing strength, and improving body composition. Its selective binding to androgen receptors in muscle and bone tissue allows for the anabolic effects of traditional steroids without the same level of side effects in other tissues.

While the benefits of RAD-140 are appealing, it is crucial to consider the potential risks and side effects associated with its use. The most common side effects include suppression of natural testosterone production, hair loss, and general adverse reactions such as headaches and nausea. 

It is essential to stick to the recommended dosage and cycle guidelines, implementing proper post-cycle therapy (PCT), and monitoring for any adverse reactions in order to minimize the risk of side effects.

FAQs

When is the best time to take RAD-140?
RAD-140 is typically taken once daily, either in the morning or evening. It's essential to maintain a consistent dosing schedule to ensure stable blood levels and optimal results.

How much RAD-140 can be taken per day?
The recommended dosage for RAD-140 ranges from 10-30mg per day, depending on the user's experience and goals. It's crucial to start with a lower dose and gradually increase it to assess tolerance and minimize potential side effects.

Is RAD-140 a strong SARM?
Yes, RAD-140 is considered one of the most potent SARMs available. It has a high anabolic to androgenic ratio, making it effective for building muscle mass and strength while minimizing androgenic side effects.

What are the effects of taking RAD-140?
RAD-140 users often report increased muscle mass, improved strength, enhanced endurance, and faster recovery times. Additionally, RAD-140 can help reduce body fat while preserving lean muscle tissue.

Can RAD-140 be stacked with other supplements or SARMs?
Yes, RAD-140 can be stacked with other SARMs or supplements to enhance its effects, although this isn’t really necessary due to RAD-140’s strength. Also, it's essential to research and understand the potential interactions and side effects before combining any compounds.

Do I need post-cycle therapy (PCT) after using RAD-140?
Yes, PCT is highly recommended after a RAD-140 cycle to help restore natural testosterone production and maintain gains. A proper PCT protocol typically includes an aromatase inhibitor such as Alchemy or 6-OXO, SERMs (Selective Estrogen Receptor Modulators), testosterone boosters and other supportive supplements.

References

[1] Christiansen AR, Lipshultz LI, Hotaling JM, Pastuszak AW. Selective androgen receptor modulators: the future of androgen therapy? Transl Androl Urol. 2020 Mar;9(Suppl 2):S135-S148. doi: 10.21037/tau.2019.11.02. PMID: 32257854; PMCID: PMC7108998.
[2] Narayanan R, Coss CC, Dalton JT. Development of selective androgen receptor modulators (SARMs). Mol Cell Endocrinol. 2018 Apr 15;465:134-142. doi: 10.1016/j.mce.2017.06.013. Epub 2017 Jun 15. PMID: 28624515; PMCID: PMC5896569. 
[3] Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ. Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology. 2014 Apr;155(4):1398-406. doi: 10.1210/en.2013-1725. Epub 2014 Jan 15. PMID: 24428527; PMCID: PMC3959610. 
[4] Furuya, K., Yamamoto, N., Ohyabu, Y., Morikyu, T., Ishige, H., Albers, M., & Endo, Y. (2013). Mechanism of the Tissue-Selective Action of the Selective Androgen Receptor Modulator S-101479. Biological and Pharmaceutical Bulletin, 36(3), 442-451.
[5] Solomon ZJ, Mirabal JR, Mazur DJ, Kohn TP, Lipshultz LI, Pastuszak AW. Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications. Sex Med Rev. 2019 Jan;7(1):84-94. doi: 10.1016/j.sxmr.2018.09.006. Epub 2018 Nov 30. PMID: 30503797; PMCID: PMC6326857.
[6] Hoffmann DB, Komrakova M, Pflug S, von Oertzen M, Saul D, Weiser L, Walde TA, Wassmann M, Schilling AF, Lehmann W, Sehmisch S. Evaluation of ostarine as a selective androgen receptor modulator in a rat model of postmenopausal osteoporosis. J Bone Miner Metab. 2019 Mar;37(2):243-255. doi: 10.1007/s00774-018-0929-9. Epub 2018 May 21. PMID: 29785666. 
[7] Bhasin S, Jasuja R. Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care. 2009 May;12(3):232-40. doi: 10.1097/MCO.0b013e32832a3d79. PMID: 19357508; PMCID: PMC2907129.
[8] Machek SB, Cardaci TD, Wilburn DT, Willoughby DS. Considerations, possible contraindications, and potential mechanisms for deleterious effect in recreational and athletic use of selective androgen receptor modulators (SARMs) in lieu of anabolic androgenic steroids: A narrative review. Steroids. 2020 Dec;164:108753. doi: 10.1016/j.steroids.2020.108753. Epub 2020 Oct 24. PMID: 33148520.
[9] Jayaraman, A., Christensen, A., Moser, V. A., Vest, R. S., Miller, C. P., Hattersley, G., & Pike, C. J. (2014). Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats. Endocrinology, 155(4), 1398-1406.
[10] Narayanan, R., Mohler, M. L., Bohl, C. E., Miller, D. D., & Dalton, J. T. (2008). Selective Androgen Receptor Modulators in Preclinical and Clinical Development. Nuclear Receptor Signaling, 6, e010.
[11] Furuya, K., Yamamoto, N., Ohyabu, Y., Morikyu, T., Ishige, H., Albers, M., & Endo, Y. (2013). Mechanism of the Tissue-Selective Action of the Selective Androgen Receptor Modulator S-101479. Biological and Pharmaceutical Bulletin, 36(3), 442-451.
[12] Dobs, A. S., Boccia, R. V., Croot, C. C., Gabrail, N. Y., Dalton, J. T., Hancock, M. L., ... & Steiner, M. S. (2013). Effects of Enobosarm on Muscle Wasting and Physical Function in Patients with Cancer: A Double-Blind, Randomised Controlled Phase 2 Trial. The Lancet Oncology, 14(4), 335-345.
[13] Morley, J. E., Anker, S. D., & von Haehling, S. (2014). Prevalence, Incidence, and Clinical Impact of Sarcopenia: Facts, Numbers, and Epidemiology—Update 2014. Journal of Cachexia, Sarcopenia and Muscle, 5(4), 253-259.
[14] Machek SB, Cardaci TD, Wilburn DT, Willoughby DS. Considerations, possible contraindications, and potential mechanisms for deleterious effect in recreational and athletic use of selective androgen receptor modulators (SARMs) in lieu of anabolic androgenic steroids: A narrative review. Steroids. 2020 Dec;164:108753. doi: 10.1016/j.steroids.2020.108753. Epub 2020 Oct 24. PMID: 33148520.
[15] Solomon, Z. J., Mirabal, J. R., Mazur, D. J., Kohn, T. P., Lipshultz, L. I., & Pastuszak, A. W. (2019). Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications. Sexual Medicine Reviews, 7(1), 84-94
[16] Furuya, K., Yamamoto, N., Ohyabu, Y., Morikyu, T., Ishige, H., Albers, M., & Endo, Y. (2013). Mechanism of the tissue-specific action of the selective androgen receptor modulator S-101479. Biological and Pharmaceutical Bulletin, 36(3), 442-451