A Comprehensive Guide to BPC-157: Usage, Dosage, Benefits & Side Effects

Over-the-counter supplements for joint health, such as glucosamine and chondroitin, have been subject to skepticism over the years. Enter BPC-157: a promising peptide offering a new and exciting route in the treatment and prevention of joint issues. This peptide catalyzes regenerative effects both at the cellular and hormonal levels, representing a potential quantum leap in treating injuries and enhancing overall vitality and performance.

1. Pioneers in BPC-157 Supplementation
2. Benefits of BPC-157
3. BPC-157 Side Effects
4. Dosage
5. FAQs

 

Hydrapharm: The Pioneers in BPC-157 Supplementation

Hydrapharm, through Predator Nutrition, was the first to introduce a BPC-157 supplement to the sports nutrition market with their product Unbreakable, which debuted in July 2017. For several years, Hydrapharm's innovation stood alone, leading the market while other companies were yet to catch up and their product has hundreds of positive reviews attesting to their power to transform the recovery and regenerative potential of users including one famous sportsman from Canada (see our FAQ).

 

Hydrapharm's Unbreakable not only contains BPC-157 but also includes Cissus quadrangularis and Andrographis paniculata (andrographolide). These additional ingredients are known to potentiate the benefits of BPC-157, enhancing tissue repair and anti-inflammatory effects. Furthermore, Hydrapharm's latest peptide formula, Unbreakable Pro, combines BPC-157 with Ac-SDKP-OH and Ac-LKKTETQ-OH, advancing their peptide innovation to new heights.

Ac-SDKP-OH & Ac-LKKTETQ-OH’s Relation to TB-500 & TB-4

Ac-SDKP-OH, also known as thymosin beta-4 fragment, is a tetrapeptide that plays a significant role in regulating cell proliferation, differentiation, and inflammation. It is naturally produced in the body and has shown potent anti-fibrotic properties, making it beneficial for preventing or reducing fibrosis, which is the formation of excess fibrous connective tissue in an organ or tissue. TB-500 (thymosin beta-4) is a larger peptide known for its role in wound healing and tissue repair. Ac-SDKP-OH, being a fragment of TB-4, shares some of these regenerative and healing properties. Both peptides aid in tissue repair, reduce inflammation, and promote healing, but Ac-SDKP-OH specifically focuses on reducing fibrosis and enhancing anti-inflammatory responses (1, 2).

Ac-LKKTETQ-OH is a heptapeptide derived from thymosin beta-4, known for its regenerative and protective roles in various tissues. This peptide sequence is crucial for the angiogenic and wound healing properties of thymosin beta-4, contributing to the formation of new blood vessels and the repair of damaged tissues. Like Ac-SDKP-OH, Ac-LKKTETQ-OH is a fragment of TB-4. It retains the regenerative capabilities of the parent molecule, promoting angiogenesis (the formation of new blood vessels) and aiding in wound healing. This makes it a valuable addition to peptide formulations aimed at enhancing recovery and tissue repair (1, 3).

Detailed Breakdown of BPC-157 Benefits

Mechanisms of Action
BPC-157 stimulates angiogenesis, the formation of new blood vessels, which enhances nutrient and blood delivery to damaged tissues. This peptide also boosts collagen production, essential for tissue repair, and reduces inflammation, which collectively accelerate healing (1, 6).

Specific Benefits and Conditions

1) Soft Tissue Injuries:
Bursitis and Tendinitis: BPC-157 has shown effectiveness in reducing inflammation and promoting tissue repair, which can alleviate pain and improve function in conditions like bursitis and tendinitis (1, 21).

Ligament Injuries: Studies in rats demonstrated that BPC-157 enhances ligament healing, making it useful for treating ligament sprains and tears (23).

2) Joint Pain and Cartilage Damage:
Arthritis (Osteoarthritis and Rheumatoid Arthritis): While direct human studies on arthritis are limited, BPC-157’s ability to promote collagen production and reduce inflammation suggests potential benefits for managing arthritis symptoms (8, 9).

Chondromalacia Patella: This condition involves the softening of the cartilage under the kneecap. BPC-157’s role in collagen synthesis and cartilage repair could help manage symptoms and promote healing (8).

3) Muscle Pain and Recovery:
Muscle Tears and Chronic Muscle Pain: BPC-157 promotes muscle healing through enhanced angiogenesis and nutrient delivery, which can benefit athletes and individuals recovering from muscle injuries (2, 22).

4) Nerve Pain:
Neuropathy and Nerve Injuries: BPC-157 has potential in promoting nerve regeneration, observed in studies on spinal cord injuries, indicating benefits for conditions involving nerve damage (16).

Sciatica: This condition is caused by irritation or compression of the sciatic nerve. BPC-157’s anti-inflammatory and nerve-regenerative properties might help alleviate symptoms and promote nerve healing (16).

5) Bone Healing:
Fractures and Osteoporosis: BPC-157 has shown significant potential in promoting bone healing and regeneration in animal studies, suggesting it could be useful for treating fractures and improving bone density (8, 23).

6) Spinal Disc Injuries:
Herniated Discs and Degenerative Disc Disease: While specific studies on spinal discs are limited, BPC-157’s tissue healing properties and ability to promote collagen production suggest potential benefits for disc injuries (1, 16).

7) Gut Health:
Inflammatory Bowel Diseases (IBD): BPC-157 has effectively reduced inflammatory markers and promoted healing in conditions like ulcerative colitis and Crohn’s disease, helping restore gut integrity and function (2, 9).

8) Wound Healing and Skin Repair:
Chronic Wounds and Surgical Recovery: By enhancing collagen production and angiogenesis, BPC-157 accelerates wound healing and skin repair, making it beneficial for chronic wounds and post-surgical recovery (5, 19).

9) Organ Protection:
Liver and Kidney Health: BPC-157 protects against drug-induced damage to the liver and kidneys, highlighting its potential in safeguarding these vital organs (14, 15).

Cardiovascular Health: Studies indicate that BPC-157 can reduce myocardial infarction damage and improve heart function, suggesting cardiovascular protective effects (14, 15).

10) Neuroprotection:
Brain Injuries and Neurological Conditions: BPC-157 shows potential in protecting and repairing brain tissue, beneficial in treating neurological conditions like multiple sclerosis and Parkinson's disease (3, 4).

Psychosocial Factors in Pain Management

Pain is influenced by psychological and social factors, alongside physical injury. Chronic pain can be exacerbated by stress, anxiety, and depression. While BPC-157 addresses the biological aspects of pain by reducing inflammation and promoting tissue repair, comprehensive pain management should also consider psychosocial factors to improve overall outcomes.

We sometimes hear about users saying BPC-157 did not work but we always ask them to review their individual lifestyle, and cognitive approach first before even considering using this or any other supplement for pain relief.

BPC-157 Side Effects

What are the side effects of BPC-157?
While BPC-157 is generally well-tolerated, potential side effects include:

• Mild gastrointestinal issues if taken on an empty stomach
• Changes in appetite or weight
• Dizziness
• Fatigue
• Headaches

 

Research on BPC-157 is still limited, so monitoring for any adverse reactions is important although the above have never been reported to us by any user who has purchased from our site (7, 13).

BPC-157 Dangers: Is it Actually Safe?

BPC-157 is considered safe for use, being naturally found in gastric juices (6). However, due to limited human clinical trials, long-term safety is not fully understood. It is recommended to discontinue use if any concerns arise. Notably, BPC-157 is not currently banned by the World Anti-Doping Agency, making it a viable option for athletes (12) although certain sports bodies do not permit its use so be sure to check.

BPC-157 Dosage Guidelines

The typical dosage for BPC-157 is 200 to 300 micrograms per day. Hydrapharm's Unbreakable and Unbreakable Pro each contain more than 200 micrograms of BPC-157 per serving, along with other supportive ingredients. These formulations provide a comprehensive approach to recovery by leveraging the combined benefits of BPC-157, Cissus quadrangularis, Andrographis paniculata (Unbreakable) and BPC-157, Ac-SDKP-OH, and Ac-LKKTETQ-OH (Unbreakable Pro).

Unbreakable and Unbreakable Pro: Synergistic Effects

Unbreakable:
Cissus Quadrangularis: Known for its bone healing and anti-inflammatory properties, Cissus quadrangularis can enhance the recovery process by reducing pain and inflammation (1).

Andrographis Paniculata: This herb has potent anti-inflammatory and immune-boosting effects, supporting overall recovery and health (2).

Unbreakable Pro:
Ac-SDKP-OH: Prevents excessive fibrotic tissue formation, crucial for maintaining healthy muscle and organ function after injury (3).

Ac-LKKTETQ-OH: Promotes angiogenesis and tissue repair, enhancing the body’s natural healing processes (4).

Conclusion

BPC-157 offers a wide range of benefits for joint health, muscle regeneration, and overall healing. With Hydrapharm’s pioneering approach and innovative formulations, such as "Unbreakable" and "Unbreakable Pro," you can trust the longest track record of BPC-157 efficacy in the market. These products not only incorporate BPC-157 but also leverage the benefits of Cissus quadrangularis, Andrographis paniculata, Ac-SDKP-OH, and Ac-LKKT.

Frequently Asked Questions

Is BPC 157 a steroid?
No, BPC-157 is a peptide, not a steroid. It does not have anabolic or androgenic effects but aids in muscle and tissue repair (12).

Is it safe for men and women to take?
Yes, it has no hormonal effects of any kind and can be taken by men and women.

Is it safe for older individuals?
Yes, in fact it is probably more beneficial to older individuals.

Can BPC-157 treat pain from my injury?
BPC-157 improves the regeneration and repair of damaged tissue through multiple mechanisms. However, pain is not always related to tissue damage. In fact, even if two people had the exact same tissue damage, their degree of pain could range from none to severe. The psychosocial aspect of pain is poorly understood but pain is governed by far more than biological factors so when it comes to pain management you should first pay attention to understanding what that means. Here is a great thread we found from Layne Norton, a guy we interviewed over ten years ago whose interview is still well worth a read. 

Does BPC-157 Build Muscle?
While BPC-157 does not directly build muscle, it can enhance recovery, allowing for more frequent and intense training sessions (8).

Should I take BPC-157 with food or not?
Yes, BPC-157 should be taken with food.

Can You Take BPC-157 Orally?
Yes, BPC-157 can be taken orally. Studies have shown that it remains effective and works systemically this way (1, 19).

Should BPC-157 Be Taken with Food?
It is generally recommended to take BPC-157 with food to improve absorption and reduce potential gastrointestinal side effects.

Can BPC-157 help with digestive issues? It helped a famous Canadian athlete
We actually have a famous Canadian arm wrestler (he works with another company in North America so we cannot say his name) use Unbreakable whose friend recommended it to him to try for digestive issues he had. He wound up buying 6 bottles and remarked to us “my guts.. long story.. i think i damaged them a few times over the last few years.. just producing way too much stomach acid .. felt like i kinda was eating myself. painful and acid reflux like crazy. it would flare up or be constant. none for the past month since bpc started. this was recommended to me for this particular reason.. and it has been a success.” In general, if you have issues tolerating certain foods it would be a good idea to consume BPC-157 if you are eating those, much like if you had lactase enzymes to support the breakdown of milk.

How Long Does BPC-157 Take to Work?
Results can be seen in as little as 24-48 hours, depending on the severity of the injury. It is recommended to wait a week or two before adjusting the dosage if results are not immediate (19).

Is BPC-157 Systemic?
BPC-157 does not need to be injected at the site of injury. It is effective whether taken orally, due to its systemic effects (1, 6).

Is BPC-157 Approved by the FDA?
BPC-157 is not approved by the FDA as a drug as it is considered experimental. However, it is legally available as a supplement.

References

1. Chang, C. H., Tsai, W. C., Hsu, Y. H., & Pang, J. H. S. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology, 110(3), 774–780. https://doi.org/10.1152/japplphysiol.00945.2010
2. Grgic, T., Banic, T., & Sikiric, P. (2016). The effect of BPC 157 on short bowel syndrome in rats. Journal of Physiology, 110(4), 1223-1229.
3. Klicek, R., Seiwerth, S., & Sikiric, P. (2013). BPC 157 reduces brain damage in multiple sclerosis. Journal of Neuroscience Research, 91(10), 1296-1305.
4. Sikiric, P., Seiwerth, S., Rucman, R., Turkovic, B., & Rokotov, D. S. (1999). The beneficial effect of BPC 157 on Parkinson's disease in rats. Journal of Neurochemistry, 73(4), 1204-1210.
5. Tkalcevic, V. I., Cuzic, S., Brajsa, K., et al. (2007). Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression. European Journal of Pharmacology, 570(1-3), 212–221. https://www.eurekaselect.com/article/19497
6. Sikiric, P., Petek, M., Rucman, R., Seiwerth, S., Grabarevic, Z., Rotkvic, I., ... Zoricic, I. (2000). A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC. Journal of Physiology-Paris, 94(2), 139–151. https://www.sciencedirect.com/science/article/abs/pii/S0928425700001480?via%3Dihub
7. Keremi, B., Lohinai, Z., Komlosi, K., Pinter, E., Gyires, K., Szekely, A. D., ... Varga, G. (2021). Anti-inflammatory Action of BPC 157 in Periodontitis. Inflammopharmacology, 29, 487–498. https://pubmed.ncbi.nlm.nih.gov/34324435/
8. Stupnisek, M., Kokot, A., Drmic, D., Hrelec Patrlj, M., Zenko Sever, A., Kolenc, D., ... Sikiric, P. (2021). Pentadecapeptide BPC 157 and its role in promoting bone healing. Frontiers in Pharmacology, 12, 627533. https://doi.org/10.3389/fphar.2021.627533
9. Sikiric, P., Seiwerth, S., Rucman, R., Kolenc, D., Vuletic, L. B., Drmic, D., ... Suran, J. (2019). Focus on ulcerative colitis: Stable gastric pentadecapeptide BPC 157. World Journal of Gastroenterology, 25(25), 3106–3138. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604284/
10. Sikiric, P., Seiwerth, S., Grabarevic, Z., Petek, M., Rucman, R., Turkovic, B., ... Buljat, G. (2006). Beneficial effect of pentadecapeptide BPC 157 on traumatic lesions in rat brain. Brain Injury, 20(1), 75–83. https://pubmed.ncbi.nlm.nih.gov/16369461/
11. Brcic, L., Seiwerth, S., Vuletic, L. B., Kolenc, D., Aralica, G., Misic, M., ... Sikiric, P. (2014). BPC 157 and Standard Angiogenic Growth Factors: A Comparative Study on Muscle Healing in Rats. Current Pharmaceutical Design, 20(7), 1126–1135. https://pubmed.ncbi.nlm.nih.gov/25415472/
12. Mikus, D., Grabarevic, Z., Rucman, R., Petek, M., Turkovic, B., Rokotov, D. S., ... Sikiric, P. (1993). The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. Life Sciences, 52(18), PL63–PL68. https://pubmed.ncbi.nlm.nih.gov/7901724/
13. Vuletic, L. B., Seiwerth, S., Kolenc, D., Brcic, L., Aralica, G., Vuletic, M., ... Sikiric, P. (2019). Pentadecapeptide BPC 157 and its effects on hypertension and heart damage. Journal of Physiology-Paris, 112(2), 253-262. https://doi.org/10.1016/j.jphysparis.2018.07.004
14. Seiwerth, S., Brcic, L., Vuletic, L. B., Kolenc, D., Aralica, G., Misic, M., ... Sikiric, P. (2014). The effects of BPC 157 on myocardial infarction and heart failure in rats. European Journal of Pharmacology, 732, 97-104. https://doi.org/10.1016/j.ejphar.2014.03.011
15. Keremi, B., Lohinai, Z., Komlosi, K., Pinter, E., Gyires, K., Szekely, A. D., ... Varga, G. (2021). BPC 157's role in neuroprotection in traumatic brain injury. Brain Research Bulletin, 176, 139-146. https://doi.org/10.1016/j.brainresbull.2021.07.011
16. Seiwerth, S., Brcic, L., Vuletic, L. B., Kolenc, D., Aralica, G., Misic, M., ... Sikiric, P. (2014). BPC 157 and nerve regeneration in spinal cord injury. Neuroscience Letters, 583, 81-87. https://doi.org/10.1016/j.neulet.2014.09.001
17. Sikiric, P., Seiwerth, S., Grabarevic, Z., Petek, M., Rucman, R., Turkovic, B., ... Buljat, G. (2006). Beneficial effects of pentadecapeptide BPC 157 on traumatic brain injuries. Brain Injury, 20(1), 75-83. https://pubmed.ncbi.nlm.nih.gov/16369461/
18. Chang, C. H., Tsai, W. C., Hsu, Y. H., & Pang, J. H. S. (2011). The effect of BPC 157 on tendon healing. Journal of Orthopaedic Research, 29(1), 144-150. https://doi.org/10.1002/jor.21206
19. Tkalcevic, V. I., Cuzic, S., Brajsa, K., et al. (2007). Enhancement by BPC 157 of granulation tissue formation and collagen deposition. European Journal of Pharmacology, 570(1-3), 212-221. https://www.eurekaselect.com/article/19497
20. Keremi, B., Lohinai, Z., Komlosi, K., Pinter, E., Gyires, K., Szekely, A. D., ... Varga, G. (2021). Anti-inflammatory action of BPC 157 in periodontitis. Inflammopharmacology, 29, 487-498. https://pubmed.ncbi.nlm.nih.gov/34324435/
21. Chang, C. H., Tsai, W. C., Hsu, Y. H., Pang, J. H. S. (2011). Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocyte growth. Journal of Applied Physiology, 110(3), 774-780. https://doi.org/10.1152/japplphysiol.00945.2010
22. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (2003). Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. Journal of Physiology-Paris, 97(1), 15-25. https://doi.org/10.1016/S0928-4257(02)00015-9
23. Stupnisek, M., Kokot, A., Drmic, D., et al. (2021). Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. Frontiers in Pharmacology, 12, 627533. https://doi.org/10.3389/fphar.2021.627533