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Types of S.A.R.Ms and Their Benefits

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Types of S.A.R.Ms and Their Benefits

To help you navigate this article on S.A.R.M.S, we've included a table of contents linking to each section:

Whats are S.A.R.M.S?
Benefits Of S.A.R.M.S over AAS
LGD 4033
MK 677
GW 501516
RAD 140
Ostarine

What are S.A.R.Ms?

S.A.R.Ms, or selective androgen receptor modulators, are a unique class of molecules that are being developed to treat diseases that are currently being treated with AAS (anabolic-androgenic steroids). Some S.A.R.Ms have even gone to trial for TRT (testosterone replacement therapy).

When S.A.R.Ms bind to the receptor they demonstrate anabolic and hypertrophic activity in both muscle and bone. This makes them ideal candidates for TRT, osteoporosis treatment and muscle wasting treatment.

For bodybuilders, S.A.R.Ms provide the benefits of traditional AAS (anabolic-androgenic steroids) - more muscle, less fat, and better bone density - while producing significantly fewer unwanted side effects (estrogen related sides and water retention).

S.A.R.Ms can have an anabolic to androgenic ratio as high as a 10:1. This is what allows them to build muscle with little to no side effects. They also typically display a high bioavailability, ensuring effective utilisation and absorption.

Benefits of S.A.R.Ms over AAS

S.A.R.Ms are nontoxic to the liver and have little effect on blood pressure. This eliminates the need for preloading and on-cycle support supplements. Subsequently, a S.A.R.M cycle will ultimately be less expensive than a traditional AAS/Ph (steroid/prohormone) cycle. The chances of estrogen-related sides and water retention are significantly lower, as well. 

S.A.R.Ms, PPAR modulators & GH secretagogues

LGD 4033

LGD 4033 a S.A.R.M like Ostarine but 12 times as powerful at only 1/3 the dose! Consequently it is more suppressive to the HPTA (Hypothalamus-Pituitary-Testes-Axis – the system of the hypothalamus, pituitary gland and gonadal glands, which plays a vital role in the development and regulation of the reproductive and immune systems). So, a SERM (selective estrogen receptor modulator) post cycle therapy is recommended.

Where Ostarine is best used in a cutting cycle, LGD has proven itself as a good bulking agent. LGD has a half-life ranging between 24 and 36 hours so daily dosing is optimal.

In a study performed at Boston University, healthy men who were given 1mg of LGD daily gained about 3 pounds in 3 weeks on average. No clinically significant changes were noted in liver function tests, PSA (prostate issue/function tests), hematocrit (testing on the ratio of the volume of red blood cells to the total volume of blood) or ECG (electrocardiogram tests, used to check the heart's rhythm and electrical activity).

However, given the potential for high estrogen side effects while using LGD, it is recommended that you have an AI like Exemestane on hand.
*Ar1macare Pro can be substituted for Elim1nate during cycle for full protection

MK 677 (Ibutamoren)

This is a non-peptidic, orally active and selective agonist of the growth hormone secretagogue (secretion-boosting) receptor. It mimics the action of ghrelin (the hormone that regulates appetite and the distribution and rate of use of energy) in the stomach, raising growth hormone and IGF-1 levels, but does not affect cortisol levels.

Human studies have shown it to increase both muscle mass and bone mineral density. Dosed at 25mg daily, Ibutamoren has been shown to increase IGF-1 levels by 60% in 6 weeks in humans. A 72% increase in IGF-1 levels was seen after 12 months.

MK 677 is non-hormonal and therefore requires no PCT after the cycle is over. It is best utilised in at least a 3 month cycle with dosage increasing each month. The optimal dosing time for MK 677 is at night directly before going to bed. You should start to notice a deeper sleep almost immediately. If you should wake up with numb or tingly hands, do not worry. This is a common side effect of the extra GH in the system.

GW 501516

This is actually not a S.A.R.M. In fact it is a PPAR Delta Modulator – a selective agonist with a high affinity for the PPAR (peroxisome proliferator-activated receptors - a group of steroid- and thyroid-sensing proteins that control the expression of genes, thereby regulating cellular development and metabolism). This modulation allows the body to utilise more glucose and create more muscle tissue.

GW also regulates the various proteins that the body uses for energy. For the user, this means an increase in energy and endurance, and it may also mean an increase in muscle mass. It is also possible that GW might have a positive effect on blood pressure and lipid profile.

Dosing is in the 7mg to 21mg range, with 14mg being the "sweet spot". The average GW cycle is typically 4 to 12 weeks. GW is non-hormonal and therefore requires no PCT. However, it does stack well with SARMS to further increase fat loss and endurance.

RAD 140

RAD 140 is very new, so there isn't a lot of real world data on it yet. However, it does look very promising, with an impressive anabolic to androgenic ratio of 90:1! This means that users can experience a wealth of muscle building effects without all the associated androgenic side effects.

RAD is powerful enough to limit the effect of testosterone on the prostate and other unwanted areas. It has even been shown to be more anabolic than testosterone, as well. Dosing appears to be in the 4mg to 12mg range, with optimal cycle length being 4 to 6 weeks. Given its shorter half-life (16 hours), RAD needs to be dosed at least twice daily.

Ostarine

This is probably the most well-known S.A.R.M. It is best used to preserve muscle mass while in a caloric deficit. Ostarine can and will suppress your natural testosterone production in longer, higher dosed cycles, so a SERM PCT is needed. Ostarine can also cause gyno in some users, so it is recommended that you have an AI, like Exemestane, on hand.

The average cycle length is 6 to 10 weeks at a dosage range of 10mg to 25mg.

Summary

Have you tried S.A.R.Ms? Would you choose them over other measures like prohormones? Please share your experiences with us via Facebook. Alternatively, check out our other informative articles or shop our range of S.A.R.Ms by following the links below.

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About the Author

Reggie Johal

Reggie Johal is the founder of Predator Nutrition, a UK based health and supplement store. Reggie owes much of his extensive strength and fitness knowledge to his former career as a Great Britain American Footballer.