Complete Guide To Nootropics - Types, Benefits & Dosage

So, you've probably heard about these so-called 'smart drugs' or cognitive enhancers that are making the rounds, right? Nootropics. They've been catching some serious attention for their brain-boosting powers. Let's unpack what they're all about, the different types out there, and why they might just be the upgrade your brain's been waiting for.

• What Are Nootropics?
• History of Nootropics
• The Science Behind Nootropics
• Benefits of Nootropics
• How to start with Nootropics?
• Nootropic stacks – what are they?
• Day or night - when is best to take nootropics?
• Safety and Side Effects
• Are nootropics legal?
• Conclusion

 

1. What Are Nootropics?
Nootropics are substances designed to improve cognitive functions—think memory, creativity, motivation—all without the crash or side effects that come with your average cup of coffee. Imagine your brain operating like the latest high-spec smartphone. Nootropics are kind of like the apps and updates that boost its performance.

2. History of Nootropics
Nootropics, starting with Piracetam discovered by Dr. Corneliu E. Giurgea, have revolutionized how we enhance memory and brain function. Originally aimed at treating sleep disorders, Piracetam laid the groundwork for cognitive enhancers that improve learning, memory, and protect the brain without major side effects. This innovation sparked a new era in cognitive enhancement, not just for treating conditions like aging and Alzheimer's but also for boosting cognitive function in healthy individuals for academic and professional success.

Over time, the variety of nootropics expanded, including both synthetic and natural options. Today, nootropics are part of the biohacking movement, reflecting a growing interest in optimizing mental performance scientifically.

3. The Science Behind Nootropics
The intricacies of how nootropics interact with neurotransmitters, particularly dopamine, are a key aspect of their potential cognitive-enhancing effects. Dopamine is a crucial neurotransmitter that plays significant roles in our reward system, motivation, memory, and attention mechanisms. Nootropics can influence the dopaminergic system in several ways, leading to enhanced cognitive functions.

Firstly, some nootropics are known to increase the release of dopamine within the brain. This can lead to improved attention and motivation, as seen in individuals with attention deficit hyperactivity disorder (ADHD) who are treated with stimulant medications. These medications, which can be considered nootropic under certain uses, work by boosting dopamine levels, thereby enhancing focus and attentiveness.

Secondly, certain nootropics may inhibit the reuptake of dopamine. By preventing dopamine from being reabsorbed into neurons, these substances can increase dopamine availability in the synaptic cleft, where it can exert its effects for longer periods. This mechanism is similar to how some antidepressants work, suggesting potential mood-enhancing benefits of nootropics as well.
Moreover, nootropics might influence the sensitivity of dopamine receptors. Enhancing receptor sensitivity could mean that even normal levels of dopamine become more effective, leading to improvements in cognitive functions without necessarily increasing dopamine production or slowing its reuptake.

4. Benefits of Nootropics
Ever watched "Limitless" and thought, "Hey, I need that brain-boosting pill!"? Well, nootropics have become the closest thing to turning us into high-functioning geniuses without needing a Hollywood script. While they will sharpen your focus and memory, unfortunately they won't suddenly unlock 100% of your brain power or have you learning Italian overnight. So, if you're expecting to crank out novels at a coffee shop or manipulate stock markets before lunch, you might want to adjust those expectations. While nootropics may not be the magical NZT-48, their benefits are still very impressive.

• Enhanced Memory

- 9-MBC (9-Methyl-β-carboline) is noted for its neuroprotective properties. [1] It's believed to stimulate neurogenesis, the process by which new neurons are formed in the brain, which is crucial for memory and learning. By potentially enhancing dopamine levels and protecting neural structures, 9-MBC may support memory retention and learning capabilities. [2]

9-MBC User Reviews: 
“It is my pleasure to give a glowing review to this wonderful product. It has been a few months since I finished the bottle of 9MBC and about ready to reorder… I am comfortable saying the claims made are valid… I would put this in my top five of all time.” ~ Karl
“ A bit pricey, but I've tried cheaper products that have done nothing, Hydrapharm sells top stuff at a price that reflects that. Will buy again.” ~ Simon

- Lion's Mane (Hericium erinaceus): A mushroom known for its nerve growth factor (NGF)-stimulating properties. NGF is essential for the growth, maintenance, and survival of neurons. [3] Studies indicate Lion's Mane's potential as a neuroprotective agent, as well as being linked to improved memory and cognitive functions, making it a valuable natural nootropic for enhancing memory. [4]

Lion’s Mane User Reviews: 
“I am very pleased with this product. Though I still feel tired, my focus at work and at home has vastly improved ” ~ Coolgirl M.
“Been using this supplement for 2 weeks now. Its supposed to increase BDNF - increasing neuroplasticity in the brain. So far my memory has improved a little bit and it provides kind of clear mentally.” ~ Fabian

• Increased Focus and Attention

- Nicotinamide Mononucleotide (NMN): NMN increases NAD+ levels, supporting cellular functions and potentially mitigating age-related decline.[5] , as well as reduce inflammaging, associated with aging. [6] Research shows NMN is well-tolerated and safe in both human and animal studies, making it an ideal supplement for increasing cellular NAD+ level. [7] By boosting NAD+ levels, NMN enhances energy metabolism and supports cognitive functions. It’s almost like having the energy of a 20-year-old with the wisdom of your current age – that's pretty much what NMN should do. A good starting point is somewhere between 250 and 500 mg, to sync with your body's natural rhythm.

Immortal User Reviews:
“Been taking for three days now alongside two other compounds from Hydrapharm… I certainly feel a lot different to before I started the cycle. Just feel 'better' and 'more alive’” ~ Kristian C.
“This stuff feels like something jumpstarted my energy leves almost to an ADHD state which feels good! Good vibe energy!! Second day with 1 capsule in the morning and feel amazing, would recommend!” ~ Ragnar

- Salidroside: Found in Rhodiola Rosea, salidroside is praised for its adaptogenic effects, helping the body resist physical, chemical, and environmental stress.[8] Studies show that Salidroside exhibits antioxidant properties, regulating oxidative stress and inflammation. [9] By reducing fatigue and combating stress, salidroside can indirectly enhance focus and mental clarity.

Salidroside User Reviews:
“Great in the morning with a cup of coffee to get your brain going, provides a nice subtle uplift to your mood.” ~ Sg
“I have used rhodiola rosea many times in the past, but I didn't feel with it the same effect that Salidroside gave to me. Most of all, it did give me a more adaptogen effect to stress” ~ Nilus
“I work early in the morning and I'm always on the lookout for nootropics that work well with minimal sides. This is one such product. Good stuff.” ~ Adam

• Improved Mood

- 5-HTP (5-Hydroxytryptophan): This natural compound is a direct precursor to serotonin, a neurotransmitter associated with mood regulation. Supplementing with 5-HTP can help increase serotonin levels, potentially improving mood, reducing symptoms of depression, and aiding in sleep. [10] [11]

5-HTP User Reviews:
“I used this while on a havoc cycle. It was great in getting me back to sleep.” ~ Taylor
“Supplemented this alongside ZMA as I have struggled with sleep for a long time. It has worked wonders - my sleep quality has improved infinitely.” ~ Sh

- Anatabine: A compound found in tobacco and other plants, anatabine has anti-inflammatory properties. While direct links to mood improvement require more research, reducing inflammation can have indirect benefits on cognitive health and mood stabilization. Research also suggests anatabine reduces inflammation, potentially aiding conditions like ulcerative colitis [12] and it can also help with weight reduction. [13]

Anatablok User Reviews:
“Necessary for a serious athlete, it does little miracle.” ~ Yacine S.
“Scientific studies have proven that it somehow mitigates the NFkB’s in our body to help control inflammation. It even worked against Traumatic Brain Injury in multiple mouse studies.” ~ Greg T.
“This product is so helpful in my joints and helping with reducing inflammation. I used it regularly every day.” ~ Tt N.
Neuroprotection

- Cycloastragenol: This compound, derived from the Astragalus plant, is known for its potential to activate telomerase, an enzyme that can protect and repair telomeres, thereby possibly contributing to cellular longevity and neuroprotection.[14] Its antioxidant properties also support brain health by combating oxidative stress.[15]

Cycloastragenol User Reviews:
“Wow absolutely love this product it's a bit pricey but well worth it” ~ John M.
“... been taking it for like 6 months now and I can say that has improved my eyesight a lot, maybe even my hairs got a little bit better” ~ Mike
“On my second bottle now. Great product but just a little bit pricey. I guess you get what you pay for though!” ~ John M

- Emoxypine: Known for its antioxidant properties, emoxypine can protect the brain from free radical damage. This protection helps maintain the health of neurons and other cells within the brain, contributing to overall neuroprotection and potentially mitigating the effects of aging on the brain.[16]

Emoxypine User Reviews:
“I've bought this for my mom, she is used to take Mexidol in Russia. It helps her to reduce the headache and Meniere's disease symptoms. This is the only place I could find this and order with delivery to France.” ~ Victoria M.
“Very satisfied with this product. My son has profound autism, this has improved his quality of life.” ~ Ann O.
“I found that emoxypine works great at reducing anxiety and even for sleep ! Even during stressful time - it really helped me! Definitely worth a try!” ~ V.V.

- NSI-189: A novel compound developed for its potential to stimulate neurogenesis. By encouraging the growth of new neurons and enhancing the brain's plasticity, NSI-189 may offer benefits in repairing brain function and improving mental health conditions.[17] [18]

Neurogenesis User Reviews:
“I'm interested in anything that can improve cognitive function long term and this product along with J-147 (also sold here) has the most promising potential for neurogenesis I've found. I can't say that's what it's doing, only that the studies suggest it works, but predator nutrition is one of the few places I'd trust to get these compounds as the brands they sell are solid.” ~ Simon

5. How to start with Nootropics?
Before diving into the world of nootropic stacks, it's wise to start with a foundational approach by trying individual nootropics first. This step-by-step method allows you to understand how your body and mind respond to each substance, ensuring you can identify which nootropics work best for you and under what conditions they are most effective. Here's how to navigate this process:

• Research: Begin by researching each nootropic's effects, potential side effects, and recommended dosages. Focus on substances that align with your cognitive or wellness goals, whether that's improved memory, enhanced focus, or better stress management.
• Start Low and Go Slow: For any new nootropic, start with a low dose to assess your tolerance and observe any effects or side effects. Gradually increase to the recommended dose as you become more comfortable with its impact on your body.
• Monitor and Journal: Keep a journal of your experiences with each nootropic, noting any changes in your cognitive functions, mood, sleep patterns, and overall well-being. This record will be invaluable in assessing the efficacy of each substance and identifying any patterns or correlations.
• Isolate Variables: Try to keep other variables constant as you test each nootropic, such as diet, sleep, and exercise habits. This isolation helps ensure that any changes you notice can be more reliably attributed to the nootropic itself rather than external factors.
• Take Breaks: Between trying different nootropics, take breaks to allow your system to reset. This approach helps prevent tolerance buildup and gives you a clearer baseline from which to evaluate the next nootropic.

After you've identified which individual nootropics work best for you, you can then consider combining them into a stack. 

6. Nootropic stacks – what are they?
A "stack" in the world of supplements, especially nootropics, is a term used to describe the practice of combining different supplements to enhance their effectiveness or to achieve a specific set of benefits. Think of it as mixing ingredients for a personalized recipe that caters exactly to what your brain needs to perform better. 

When it comes to nootropic stacks, the idea is to combine substances that complement each other. This could mean one supplement helps improve memory while another boosts your concentration, and yet another keeps you calm (especially before an exam). Together, they work better than if you were taking them separately. This is because some nootropics can enhance the positive effects of others, or even reduce possible side effects, making the combined effect more powerful than the sum of its parts.

Nootropic stacks are particularly popular because they can be customized. Everyone's brain chemistry is a little different, and what works for one person might not work for another. By creating a stack, you can fine-tune the combination of nootropics to fit your own cognitive needs and goals, whether that's to study better, stay focused at work, or simply keep your brain healthy over time. 
Creating an effective nootropic stack often requires some experimentation and research. It's about understanding not just the benefits of each supplement, but how they interact with each other. That way, you can create a combination that's just right for you, enhancing your cognitive function in a balanced and effective way.

7. Day or night - when is best to take nootropics?
Deciding whether to take nootropics during the day or at night isn't a one-size-fits-all answer—it really boils down to your lifestyle, goals, and how your body reacts to them. In our quest to help you choose the best time to take them, we are listing the pros and cons of day take vs evening take. 

Taking Nootropics During the Day:
- Pros: If your main goal is to boost focus, energy, and productivity, day time is your best bet. Taking nootropics in the morning or early afternoon can help sharpen your cognitive functions, making it easier to tackle your to-do list, study, or engage in any brain-intensive tasks.
- Cons: Depending on what you're taking, some nootropics might make it harder for you to wind down in the evening, especially if they have stimulating effects similar to caffeine.
Ideal for: Day-takers are usually students, professionals, or anyone needing that mental clarity and energy to stay productive throughout the day.

Taking Nootropics At Night:
- Pros: Some nootropics are geared towards enhancing sleep quality, brain recovery, and memory consolidation while you snooze. If your nootropic supports relaxation or has sleep-promoting properties, taking it in the evening could enhance your night's rest and brain's ability to repair and grow.
- Cons: Taking stimulating nootropics at night could backfire, leading to restlessness and difficulty falling asleep, which defeats the purpose if you’re aiming for a cognitive boost.
Ideal for: Night owls, creative professionals who work late, or anyone focusing on long-term brain health and memory might prefer evening doses, especially if their nootropic aids in relaxation and recovery.

It's important to remember that everyone's different and you need to monitor your response to the particular nootropics. You may find a split dose works best, with energy-boosting nootropics taken in the morning and relaxation-supporting ones in the evening. Always start with low doses to see how you respond and adjust as needed. 

8. Safety and Side Effects
While nootropics are generally considered safe, especially those that are naturally occurring or are dietary supplements, synthetic and prescription nootropics can have side effects. Common side effects include insomnia, anxiety, and in some cases, dependency. It's essential to approach nootropics with caution, particularly synthetic ones and prescription drugs used off-label.

9. Are nootropics legal?
Across different countries, the legal status of nootropics can vary greatly. Supplements such as vitamins, minerals, and natural extracts like caffeine are generally legal and can be easily purchased. However, when it comes to prescription-based nootropics or synthetic substances, the rules can get stricter. Medications like Modafinil, often sought after for cognitive enhancement, require a prescription in many regions due to their potent effects and potential for misuse.

The distinction in legality isn't just about whether you can buy these substances but also concerns their distribution and sale. Some nootropics fall into a regulatory gray zone—being legal for personal use, but not for sale without authorization. This category often includes substances praised within the nootropic community for their brain-boosting benefits.
Before venturing into the world of nootropics, doing your homework on the legal requirements in your area is crucial. This means not only verifying the legal status of the substances you're interested in, but also understanding the implications of purchasing and possessing them. 

10. Conclusion
In the pursuit of peak cognitive performance, nootropics have emerged as a beacon for anyone aiming to enhance their mental capabilities. Whether it's powering through late-night study sessions, maintaining unwavering focus in high-demand professions, or simply seeking an edge in daily cognitive functions, nootropics offer a promising solution. The allure of these cognitive enhancers lies in their potential to fine-tune the mind's performance, making tasks such as learning, memory retention, and concentration not only more manageable, but also more efficient.

At the core of choosing the right nootropic is the understanding that not all supplements are created equal. The efficacy of a nootropic greatly depends on its formulation, quality of ingredients, and the reliability of the brand behind it. At Predator Nutrition our goal has always been and continues to be to deliver supplements that not only meet, but exceed your expectations through rigorous scientific research and precise dosing. This commitment ensures that you, our customer, have access to nootropics that are both safe and potent, capable of supporting your cognitive goals.

If you are looking to explore the world of nootropics further, then we highly recommend checking our section on Nootropics here, where aside from products by our brand, you will also find Hydrapharm, which is famous for their focus on scientifically researched, properly dosed products. 
As the key to unlocking the full potential of your mind lies in making informed decisions, our customer service representatives are more than happy to help you decide on what supplements to choose and support your journey towards improved focus and overall mental well-being.

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