Antaeus labs: Titan

You can always count on Antaeus Labs to uncover new ingredients which push the boundaries of sports nutrition and in Titan we have the world'd first supplement to feature the exciting new natural muscle builder, tomatadine.

What is Tomatadine?

Tomatadine, as the name might give away, is a natural compound found in tomatoes which has been shown in recent research to have a profound anabolic effect in the body.

TITAN IS Tomatidine -- simply the most potent natural anabolic available. [1-3] In a direct comparison to ursolic acid, it was shown to be nearly 10-fold more potent. It was also discovered to be nearly 5-fold more orally bioavailable. It increases mTOR signalling in skeletal muscle, inhibits the ATF4 pathway, and dramatically stimulates protein synthesis. Of particular benefit to power athletes and bodybuilders is the fact that it stimulates growth primarily in Type IIb and Type IIx muscle fibers -- the power fibers with the most potential for growth.

Although tomatidine is, as previously mentioned, more orally bioavailable than ursolic acid, it still displays extremely poor aqueous solubility -- estimated at 0.000189 mg/mL [4] -- which places hard limits on its oral bioavailability. To sidestep this issue, we've complexed tomatidine with shilajit. Shilajit, which has been used as a tonic and rejuvenating agent for centuries, is a fully water-soluble mixture of fulvic acids, humic acids, and minerals. Much like cyclodextrins, it is capable of binding small molecules like tomatidine and forming amorphous, water-soluble complexes. [5-7] Our tomatidine-shilajit complex is orders of magnitude more water-soluble than pure tomatidine, a fact which boosts its bioavailability to heights otherwise out of reach.

The fact that shilajit has itself been shown to assist with muscle growth, and boost testosterone levels in healthy young men, is just a bonus. [8-9]

As is the fact that tomatidine is proven heart-healthy, and may be able to assist with cholesterol and lipid support. [10-11]

...The important thing is that TITAN is the most potent natural anabolic available.

Accept no substitute. TITAN has been rigorously tested, results are publicly available, and a patent is pending. TITAN uses top-quality tomatidine (standardized to over 95% purity) and shilajit (standardized to 50%+ fulvic acids).

References

[1. Dyle MC, Ebert SM, Cook DP, et al. Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy. J Biol Chem. 2014;289(21):14913-24.
2. Ebert SM, Dyle MC, Bullard SA, et al. Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. J Biol Chem. 2015;290(42):25497-511.
3. Adams CM, Ebert SM, Dyle MC. Use of mRNA expression signatures to discover small molecule inhibitors of skeletal muscle atrophy. Curr Opin Clin Nutr Metab Care. 2015;18(3):263-8.
4. Available at: http://www.hmdb.ca/metabolites/HMDB34731. Accessed November 9, 2016.
5. Agarwal SP, Anwer MK, Aqil M. Complexation of furosemide with fulvic acid extracted from shilajit: a novel approach. Drug Dev Ind Pharm. 2008;34(5):506-11.
6. Mirza MA, Ahmad N, Agarwal SP, Mahmood D, Khalid anwer M, Iqbal Z. Comparative evaluation of humic substances in oral drug delivery. Results Pharma Sci. 2011;1(1):16-26.
7. Mirza MA, Agarwal SP, Rahman MA, et al. Role of humic acid on oral drug delivery of an antiepileptic drug. Drug Dev Ind Pharm. 2011;37(3):310-9.
8. Das A, Datta S, Rhea B, et al. The Human Skeletal Muscle Transcriptome in Response to Oral Shilajit Supplementation. J Med Food. 2016;19(7):701-9.
9. Pandit S, Biswas S, Jana U, De RK, Mukhopadhyay SC, Biswas TK. Clinical evaluation of purified Shilajit on testosterone levels in healthy volunteers. Andrologia. 2016;48(5):570-5.
10. Fujiwara Y, Kiyota N, Tsurushima K, et al. Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting acyl-CoA:cholesterol acyl-transferase (ACAT). J Agric Food Chem. 2012;60(10):2472-9.
11. Friedman M. Anticarcinogenic, cardioprotective, and other health benefits of tomato compounds lycopene, α-tomatine, and tomatidine in pure form and in fresh and processed tomatoes. J Agric Food Chem. 2013;61(40):9534-50.